Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones

Armando P. Ramirez, Andrew M. Thomas, Keith Woerpel

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Treatment of γ,δ-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.

Original languageEnglish (US)
Pages (from-to)507-510
Number of pages4
JournalOrganic Letters
Volume11
Issue number3
DOIs
StatePublished - Feb 5 2009

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Alkenes
Ketones
hydrogen peroxide
entry
ketones
Hydrogen Peroxide
alkenes
Substitution reactions
substitutes
preparation
acids
Acids
1,2,4-trioxane

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones. / Ramirez, Armando P.; Thomas, Andrew M.; Woerpel, Keith.

In: Organic Letters, Vol. 11, No. 3, 05.02.2009, p. 507-510.

Research output: Contribution to journalArticle

Ramirez, Armando P. ; Thomas, Andrew M. ; Woerpel, Keith. / Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones. In: Organic Letters. 2009 ; Vol. 11, No. 3. pp. 507-510.
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