Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain

John H. Gilmore, Lauren C. Smith, Honor M. Wolfe, Barbara S. Hertzberg, J. Keith Smith, Nancy C. Chescheir, Dianne D. Evans, Chaeryon Kang, Robert M. Hamer, Weili Lin, Guido Gerig

    Research output: Contribution to journalArticle

    Abstract

    Background: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development. Methods: We performed neonatal magnetic resonance imaging on 34 children with isolated mild ventriculomegaly (MVM; width of the atrium of the lateral ventricle ≥ 1.0 cm) on prenatal ultrasound and 34 age- and sex-matched control subjects with normal prenatal ventricle size. Lateral ventricle and cortical gray and white matter volumes were assessed. Fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum and corticospinal white matter tracts were determined obtained using quantitative tractography. Results: Neonates with prenatal MVM had significantly larger lateral ventricle volumes than matched control subjects (286.4%; p < .0001). Neonates with MVM also had significantly larger intracranial volumes (ICV; 7.1%, p = .0063) and cortical gray matter volumes (10.9%, p = .0004) compared with control subjects. Diffusion tensor imaging tractography revealed a significantly greater MD in the corpus callosum and corticospinal tracts, whereas FA was significantly smaller in several white matter tract regions. Conclusions: Prenatal enlargement of the lateral ventricle is associated with enlargement of the lateral ventricles after birth, as well as greater gray matter volumes and delayed or abnormal maturation of white matter. It is suggested that prenatal ventricle volume is an early structural marker of altered development of the cerebral cortex and may be a marker of risk for neuropsychiatric disorders associated with ventricle enlargement.

    Original languageEnglish (US)
    Pages (from-to)1069-1076
    Number of pages8
    JournalBiological Psychiatry
    Volume64
    Issue number12
    DOIs
    StatePublished - Dec 15 2008

    Fingerprint

    Lateral Ventricles
    Brain
    Corpus Callosum
    Anisotropy
    Newborn Infant
    Pyramidal Tracts
    Diffusion Tensor Imaging
    Cerebral Cortex
    Psychiatry
    Magnetic Resonance Imaging
    Parturition
    White Matter

    Keywords

    • Autism
    • cortex
    • diffusion tensor imaging
    • lateral ventricle
    • magnetic resonance imaging
    • schizophrenia
    • ultrasound

    ASJC Scopus subject areas

    • Biological Psychiatry

    Cite this

    Gilmore, J. H., Smith, L. C., Wolfe, H. M., Hertzberg, B. S., Smith, J. K., Chescheir, N. C., ... Gerig, G. (2008). Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain. Biological Psychiatry, 64(12), 1069-1076. https://doi.org/10.1016/j.biopsych.2008.07.031

    Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain. / Gilmore, John H.; Smith, Lauren C.; Wolfe, Honor M.; Hertzberg, Barbara S.; Smith, J. Keith; Chescheir, Nancy C.; Evans, Dianne D.; Kang, Chaeryon; Hamer, Robert M.; Lin, Weili; Gerig, Guido.

    In: Biological Psychiatry, Vol. 64, No. 12, 15.12.2008, p. 1069-1076.

    Research output: Contribution to journalArticle

    Gilmore, JH, Smith, LC, Wolfe, HM, Hertzberg, BS, Smith, JK, Chescheir, NC, Evans, DD, Kang, C, Hamer, RM, Lin, W & Gerig, G 2008, 'Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain', Biological Psychiatry, vol. 64, no. 12, pp. 1069-1076. https://doi.org/10.1016/j.biopsych.2008.07.031
    Gilmore JH, Smith LC, Wolfe HM, Hertzberg BS, Smith JK, Chescheir NC et al. Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain. Biological Psychiatry. 2008 Dec 15;64(12):1069-1076. https://doi.org/10.1016/j.biopsych.2008.07.031
    Gilmore, John H. ; Smith, Lauren C. ; Wolfe, Honor M. ; Hertzberg, Barbara S. ; Smith, J. Keith ; Chescheir, Nancy C. ; Evans, Dianne D. ; Kang, Chaeryon ; Hamer, Robert M. ; Lin, Weili ; Gerig, Guido. / Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain. In: Biological Psychiatry. 2008 ; Vol. 64, No. 12. pp. 1069-1076.
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    abstract = "Background: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development. Methods: We performed neonatal magnetic resonance imaging on 34 children with isolated mild ventriculomegaly (MVM; width of the atrium of the lateral ventricle ≥ 1.0 cm) on prenatal ultrasound and 34 age- and sex-matched control subjects with normal prenatal ventricle size. Lateral ventricle and cortical gray and white matter volumes were assessed. Fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum and corticospinal white matter tracts were determined obtained using quantitative tractography. Results: Neonates with prenatal MVM had significantly larger lateral ventricle volumes than matched control subjects (286.4{\%}; p < .0001). Neonates with MVM also had significantly larger intracranial volumes (ICV; 7.1{\%}, p = .0063) and cortical gray matter volumes (10.9{\%}, p = .0004) compared with control subjects. Diffusion tensor imaging tractography revealed a significantly greater MD in the corpus callosum and corticospinal tracts, whereas FA was significantly smaller in several white matter tract regions. Conclusions: Prenatal enlargement of the lateral ventricle is associated with enlargement of the lateral ventricles after birth, as well as greater gray matter volumes and delayed or abnormal maturation of white matter. It is suggested that prenatal ventricle volume is an early structural marker of altered development of the cerebral cortex and may be a marker of risk for neuropsychiatric disorders associated with ventricle enlargement.",
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    AU - Gilmore, John H.

    AU - Smith, Lauren C.

    AU - Wolfe, Honor M.

    AU - Hertzberg, Barbara S.

    AU - Smith, J. Keith

    AU - Chescheir, Nancy C.

    AU - Evans, Dianne D.

    AU - Kang, Chaeryon

    AU - Hamer, Robert M.

    AU - Lin, Weili

    AU - Gerig, Guido

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    N2 - Background: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development. Methods: We performed neonatal magnetic resonance imaging on 34 children with isolated mild ventriculomegaly (MVM; width of the atrium of the lateral ventricle ≥ 1.0 cm) on prenatal ultrasound and 34 age- and sex-matched control subjects with normal prenatal ventricle size. Lateral ventricle and cortical gray and white matter volumes were assessed. Fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum and corticospinal white matter tracts were determined obtained using quantitative tractography. Results: Neonates with prenatal MVM had significantly larger lateral ventricle volumes than matched control subjects (286.4%; p < .0001). Neonates with MVM also had significantly larger intracranial volumes (ICV; 7.1%, p = .0063) and cortical gray matter volumes (10.9%, p = .0004) compared with control subjects. Diffusion tensor imaging tractography revealed a significantly greater MD in the corpus callosum and corticospinal tracts, whereas FA was significantly smaller in several white matter tract regions. Conclusions: Prenatal enlargement of the lateral ventricle is associated with enlargement of the lateral ventricles after birth, as well as greater gray matter volumes and delayed or abnormal maturation of white matter. It is suggested that prenatal ventricle volume is an early structural marker of altered development of the cerebral cortex and may be a marker of risk for neuropsychiatric disorders associated with ventricle enlargement.

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    KW - cortex

    KW - diffusion tensor imaging

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    KW - magnetic resonance imaging

    KW - schizophrenia

    KW - ultrasound

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