Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2

Amanda E. Lyall, Sandra Woolson, Honor M. Wolfe, Barbara Davis Goldman, J. Steven Reznick, Robert M. Hamer, Weili Lin, Martin Styner, Guido Gerig, John H. Gilmore

    Research output: Contribution to journalArticle

    Abstract

    Background: Enlargement of the lateral ventricles is thought to originate from abnormal prenatal brain development and is associated with neurodevelopmental disorders. Fetal isolated mild ventriculomegaly (MVM) is associated with the enlargement of lateral ventricle volumes in the neonatal period and developmental delays in early childhood. However, little is known about postnatal brain development in these children. Methods: Twenty-eight children with fetal isolated MVM and 56 matched controls were followed at ages 1 and 2. years with structural imaging on a 3T Siemens scanner and assessment of cognitive development with the Mullen Scales of Early Learning. Lateral ventricle, total gray and white matter volumes, and Mullen cognitive composite scores and subscale scores were compared between groups. Results: Compared to controls, children with prenatal isolated MVM had significantly larger lateral ventricle volumes at ages 1 and 2. years. Lateral ventricle volume at 1 and 2. years of age was significantly correlated with prenatal ventricle size. Enlargement of the lateral ventricles was associated with increased intracranial volumes and increased gray and white matter volumes. Children with MVM had Mullen composite scores similar to controls, although there was evidence of delay in fine motor and expressive language skills. Conclusions: Children with prenatal MVM have persistent enlargement of the lateral ventricles through the age of 2. years; this enlargement is associated with increased gray and white matter volumes and some evidence of delay in fine motor and expressive language development. Further study is needed to determine if enlarged lateral ventricles are associated with increased risk for neurodevelopmental disorders.

    Original languageEnglish (US)
    Pages (from-to)691-698
    Number of pages8
    JournalEarly Human Development
    Volume88
    Issue number8
    DOIs
    StatePublished - Aug 2012

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    Lateral Ventricles
    Language Development
    Brain
    Child Development
    Language
    Learning

    Keywords

    • Cognitive development
    • Gray matter
    • Magnetic resonance imaging
    • Ultrasound
    • White matter

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology

    Cite this

    Lyall, A. E., Woolson, S., Wolfe, H. M., Goldman, B. D., Reznick, J. S., Hamer, R. M., ... Gilmore, J. H. (2012). Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2. Early Human Development, 88(8), 691-698. https://doi.org/10.1016/j.earlhumdev.2012.02.003

    Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2. / Lyall, Amanda E.; Woolson, Sandra; Wolfe, Honor M.; Goldman, Barbara Davis; Reznick, J. Steven; Hamer, Robert M.; Lin, Weili; Styner, Martin; Gerig, Guido; Gilmore, John H.

    In: Early Human Development, Vol. 88, No. 8, 08.2012, p. 691-698.

    Research output: Contribution to journalArticle

    Lyall, AE, Woolson, S, Wolfe, HM, Goldman, BD, Reznick, JS, Hamer, RM, Lin, W, Styner, M, Gerig, G & Gilmore, JH 2012, 'Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2', Early Human Development, vol. 88, no. 8, pp. 691-698. https://doi.org/10.1016/j.earlhumdev.2012.02.003
    Lyall, Amanda E. ; Woolson, Sandra ; Wolfe, Honor M. ; Goldman, Barbara Davis ; Reznick, J. Steven ; Hamer, Robert M. ; Lin, Weili ; Styner, Martin ; Gerig, Guido ; Gilmore, John H. / Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2. In: Early Human Development. 2012 ; Vol. 88, No. 8. pp. 691-698.
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    AU - Lyall, Amanda E.

    AU - Woolson, Sandra

    AU - Wolfe, Honor M.

    AU - Goldman, Barbara Davis

    AU - Reznick, J. Steven

    AU - Hamer, Robert M.

    AU - Lin, Weili

    AU - Styner, Martin

    AU - Gerig, Guido

    AU - Gilmore, John H.

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    N2 - Background: Enlargement of the lateral ventricles is thought to originate from abnormal prenatal brain development and is associated with neurodevelopmental disorders. Fetal isolated mild ventriculomegaly (MVM) is associated with the enlargement of lateral ventricle volumes in the neonatal period and developmental delays in early childhood. However, little is known about postnatal brain development in these children. Methods: Twenty-eight children with fetal isolated MVM and 56 matched controls were followed at ages 1 and 2. years with structural imaging on a 3T Siemens scanner and assessment of cognitive development with the Mullen Scales of Early Learning. Lateral ventricle, total gray and white matter volumes, and Mullen cognitive composite scores and subscale scores were compared between groups. Results: Compared to controls, children with prenatal isolated MVM had significantly larger lateral ventricle volumes at ages 1 and 2. years. Lateral ventricle volume at 1 and 2. years of age was significantly correlated with prenatal ventricle size. Enlargement of the lateral ventricles was associated with increased intracranial volumes and increased gray and white matter volumes. Children with MVM had Mullen composite scores similar to controls, although there was evidence of delay in fine motor and expressive language skills. Conclusions: Children with prenatal MVM have persistent enlargement of the lateral ventricles through the age of 2. years; this enlargement is associated with increased gray and white matter volumes and some evidence of delay in fine motor and expressive language development. Further study is needed to determine if enlarged lateral ventricles are associated with increased risk for neurodevelopmental disorders.

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