Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers

John D. Merriman, Bradley E. Aouizerat, Dale J. Langford, Bruce A. Cooper, Christina R. Baggott, Janine K. Cataldo, Anand Dhruva, Laura Dunn, Claudia West, Steven M. Paul, Christine S. Ritchie, Patrick S. Swift, Christine Miaskowski

Research output: Contribution to journalArticle

Abstract

Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalBiological Research for Nursing
Volume16
Issue number2
DOIs
StatePublished - Apr 2014

Fingerprint

Caregivers
Single Nucleotide Polymorphism
Interleukin-6
Cytokines
Genetic Models
Genes
Comorbidity
Radiotherapy
Alleles
Confidence Intervals
Growth

Keywords

  • attention
  • cancer
  • cytokines
  • genetic association studies
  • inflammation
  • radiotherapy

ASJC Scopus subject areas

  • Research and Theory

Cite this

Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers. / Merriman, John D.; Aouizerat, Bradley E.; Langford, Dale J.; Cooper, Bruce A.; Baggott, Christina R.; Cataldo, Janine K.; Dhruva, Anand; Dunn, Laura; West, Claudia; Paul, Steven M.; Ritchie, Christine S.; Swift, Patrick S.; Miaskowski, Christine.

In: Biological Research for Nursing, Vol. 16, No. 2, 04.2014, p. 152-159.

Research output: Contribution to journalArticle

Merriman, John D. ; Aouizerat, Bradley E. ; Langford, Dale J. ; Cooper, Bruce A. ; Baggott, Christina R. ; Cataldo, Janine K. ; Dhruva, Anand ; Dunn, Laura ; West, Claudia ; Paul, Steven M. ; Ritchie, Christine S. ; Swift, Patrick S. ; Miaskowski, Christine. / Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers. In: Biological Research for Nursing. 2014 ; Vol. 16, No. 2. pp. 152-159.
@article{e979a1ae569c4ca8b183809180f3a741,
title = "Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers",
abstract = "Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5{\%}), moderate-to-high (48.0{\%}), and high (15.5{\%}) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare {"}G{"} allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95{\%} confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.",
keywords = "attention, cancer, cytokines, genetic association studies, inflammation, radiotherapy",
author = "Merriman, {John D.} and Aouizerat, {Bradley E.} and Langford, {Dale J.} and Cooper, {Bruce A.} and Baggott, {Christina R.} and Cataldo, {Janine K.} and Anand Dhruva and Laura Dunn and Claudia West and Paul, {Steven M.} and Ritchie, {Christine S.} and Swift, {Patrick S.} and Christine Miaskowski",
year = "2014",
month = "4",
doi = "10.1177/1099800413479441",
language = "English (US)",
volume = "16",
pages = "152--159",
journal = "Biological Research for Nursing",
issn = "1099-8004",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers

AU - Merriman, John D.

AU - Aouizerat, Bradley E.

AU - Langford, Dale J.

AU - Cooper, Bruce A.

AU - Baggott, Christina R.

AU - Cataldo, Janine K.

AU - Dhruva, Anand

AU - Dunn, Laura

AU - West, Claudia

AU - Paul, Steven M.

AU - Ritchie, Christine S.

AU - Swift, Patrick S.

AU - Miaskowski, Christine

PY - 2014/4

Y1 - 2014/4

N2 - Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.

AB - Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.

KW - attention

KW - cancer

KW - cytokines

KW - genetic association studies

KW - inflammation

KW - radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84894519801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894519801&partnerID=8YFLogxK

U2 - 10.1177/1099800413479441

DO - 10.1177/1099800413479441

M3 - Article

C2 - 23482714

AN - SCOPUS:84894519801

VL - 16

SP - 152

EP - 159

JO - Biological Research for Nursing

JF - Biological Research for Nursing

SN - 1099-8004

IS - 2

ER -