Predictors of accidental fatal drug overdose among a cohort of injection drug users

P. T. O'Driscoll, J. McGough, Holly Hagan, H. Thiede, C. Critchlow, E. R. Alexander

Research output: Contribution to journalArticle

Abstract

Objectives. This study evaluated factors associated with accidental fatal drug overdose among a cohort of injection drug users (IDUs). Methods. In a prospective cohort study of 2849 IDUs in King County, Washington, deaths were identified by electronically merging subject identifiers with death certificate records. Univariate and multivariate Cox regression analyses were performed to identify predictors of overdose mortality. Results. Thirty-two overdoses were observed. Independent predictors of overdose mortality were bisexual sexual orientation (relative risk [RR]=4,86; 95% confidence interval [CI]=2.30, 13.2), homelessness (RR=2.30; 95% CI=1.06, 5.01), infrequent injection of speedballs (RR=5.36; 95% CI=1.58, 18.1), daily use of powdered cocaine (RR=4.84; 95% CI=1.13, 20.8), and daily use of poppers (RR=22.0; 95% CI=1.74, 278). Conclusions. Sexual orientation, homelessness, and drug use identify IDUs who may benefit from targeted interventions.

Original languageEnglish (US)
Pages (from-to)984-987
Number of pages4
JournalAmerican Journal of Public Health
Volume91
Issue number6
StatePublished - 2001

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Drug Overdose
Drug Users
Confidence Intervals
Injections
Homeless Persons
Death Certificates
Sexual Behavior
Mortality
Cocaine
Cohort Studies
Regression Analysis
Prospective Studies
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

O'Driscoll, P. T., McGough, J., Hagan, H., Thiede, H., Critchlow, C., & Alexander, E. R. (2001). Predictors of accidental fatal drug overdose among a cohort of injection drug users. American Journal of Public Health, 91(6), 984-987.

Predictors of accidental fatal drug overdose among a cohort of injection drug users. / O'Driscoll, P. T.; McGough, J.; Hagan, Holly; Thiede, H.; Critchlow, C.; Alexander, E. R.

In: American Journal of Public Health, Vol. 91, No. 6, 2001, p. 984-987.

Research output: Contribution to journalArticle

O'Driscoll, PT, McGough, J, Hagan, H, Thiede, H, Critchlow, C & Alexander, ER 2001, 'Predictors of accidental fatal drug overdose among a cohort of injection drug users', American Journal of Public Health, vol. 91, no. 6, pp. 984-987.
O'Driscoll PT, McGough J, Hagan H, Thiede H, Critchlow C, Alexander ER. Predictors of accidental fatal drug overdose among a cohort of injection drug users. American Journal of Public Health. 2001;91(6):984-987.
O'Driscoll, P. T. ; McGough, J. ; Hagan, Holly ; Thiede, H. ; Critchlow, C. ; Alexander, E. R. / Predictors of accidental fatal drug overdose among a cohort of injection drug users. In: American Journal of Public Health. 2001 ; Vol. 91, No. 6. pp. 984-987.
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AU - Critchlow, C.

AU - Alexander, E. R.

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N2 - Objectives. This study evaluated factors associated with accidental fatal drug overdose among a cohort of injection drug users (IDUs). Methods. In a prospective cohort study of 2849 IDUs in King County, Washington, deaths were identified by electronically merging subject identifiers with death certificate records. Univariate and multivariate Cox regression analyses were performed to identify predictors of overdose mortality. Results. Thirty-two overdoses were observed. Independent predictors of overdose mortality were bisexual sexual orientation (relative risk [RR]=4,86; 95% confidence interval [CI]=2.30, 13.2), homelessness (RR=2.30; 95% CI=1.06, 5.01), infrequent injection of speedballs (RR=5.36; 95% CI=1.58, 18.1), daily use of powdered cocaine (RR=4.84; 95% CI=1.13, 20.8), and daily use of poppers (RR=22.0; 95% CI=1.74, 278). Conclusions. Sexual orientation, homelessness, and drug use identify IDUs who may benefit from targeted interventions.

AB - Objectives. This study evaluated factors associated with accidental fatal drug overdose among a cohort of injection drug users (IDUs). Methods. In a prospective cohort study of 2849 IDUs in King County, Washington, deaths were identified by electronically merging subject identifiers with death certificate records. Univariate and multivariate Cox regression analyses were performed to identify predictors of overdose mortality. Results. Thirty-two overdoses were observed. Independent predictors of overdose mortality were bisexual sexual orientation (relative risk [RR]=4,86; 95% confidence interval [CI]=2.30, 13.2), homelessness (RR=2.30; 95% CI=1.06, 5.01), infrequent injection of speedballs (RR=5.36; 95% CI=1.58, 18.1), daily use of powdered cocaine (RR=4.84; 95% CI=1.13, 20.8), and daily use of poppers (RR=22.0; 95% CI=1.74, 278). Conclusions. Sexual orientation, homelessness, and drug use identify IDUs who may benefit from targeted interventions.

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