Predictive genomics of cardioembolic stroke

Rachel Badovinac Ramoni, Blanca E. Himes, Michele M. Sale, Karen L. Furie, Marco F. Ramoni

Research output: Contribution to journalArticle

Abstract

Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver operating characteristic curve relative to that of the individual single nucleotide polymorphism with the highest prognostic performance (area under the receiver operating characteristic curve=60%).

Original languageEnglish (US)
JournalStroke
Volume40
Issue number3 SUPPL. 1
DOIs
StatePublished - Mar 2009

Fingerprint

Genomics
ROC Curve
Stroke
Single Nucleotide Polymorphism
Outcome Assessment (Health Care)
Genes

Keywords

  • Bayesian networks
  • Genetics
  • Ischemic stroke
  • Prediction
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Ramoni, R. B., Himes, B. E., Sale, M. M., Furie, K. L., & Ramoni, M. F. (2009). Predictive genomics of cardioembolic stroke. Stroke, 40(3 SUPPL. 1). https://doi.org/10.1161/STROKEAHA.108.533273

Predictive genomics of cardioembolic stroke. / Ramoni, Rachel Badovinac; Himes, Blanca E.; Sale, Michele M.; Furie, Karen L.; Ramoni, Marco F.

In: Stroke, Vol. 40, No. 3 SUPPL. 1, 03.2009.

Research output: Contribution to journalArticle

Ramoni, RB, Himes, BE, Sale, MM, Furie, KL & Ramoni, MF 2009, 'Predictive genomics of cardioembolic stroke', Stroke, vol. 40, no. 3 SUPPL. 1. https://doi.org/10.1161/STROKEAHA.108.533273
Ramoni RB, Himes BE, Sale MM, Furie KL, Ramoni MF. Predictive genomics of cardioembolic stroke. Stroke. 2009 Mar;40(3 SUPPL. 1). https://doi.org/10.1161/STROKEAHA.108.533273
Ramoni, Rachel Badovinac ; Himes, Blanca E. ; Sale, Michele M. ; Furie, Karen L. ; Ramoni, Marco F. / Predictive genomics of cardioembolic stroke. In: Stroke. 2009 ; Vol. 40, No. 3 SUPPL. 1.
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