Post-training reversible inactivation of the rat's basolateral amygdala interferes with hippocampus-dependent place avoidance memory in a time-dependent manner

Abbas Ali Vafaei, Karel Jezek, Jan Bures, André A. Fenton, Ali Rashidy-Pour

Research output: Contribution to journalArticle

Abstract

In this study, tetrodotoxin (TTX) inactivation was employed to evaluate the involvement of the rat's basolateral amygdala (BLA) in hippocampus-dependent spatial memory using a place avoidance learning task. Rats were trained in single 30 min session to avoid a 60° segment of the stable circular (80-cm diameter) arena, entering which was punished by a mild shock. Bilateral injections of TTX or saline were made either immediately, 1 or 2 h after training. Retention was tested 24 h later in a 30 min extinction session. Retention was impaired when both BLA inactivated immediately or 1 h after training, but not 2 h after training. These data indicate that activity in the BLA, at least 60 min after training, is necessary for the post-training processing of a hippocampus-dependent place avoidance memory.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalNeurobiology of Learning and Memory
Volume88
Issue number1
DOIs
StatePublished - Jul 1 2007

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Keywords

  • Basolateral amygdala
  • Cognition
  • Functional ablation
  • Hippocampus
  • Navigation
  • Place avoidance
  • Tetrodotoxin

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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