Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research

Jane M. Carlton, Sarah K. Volkman, Swapna Uplekar, Daniel N. Hupalo, João Marcelo Pereira Alves, Liwang Cui, Martin Donnelly, David S. Roos, Omar S. Harb, Monica Acosta, Andrew Read, Paulo E M Ribolla, Om P. Singh, Neena Valecha, Samuel C. Wassmer, Marcelo Ferreira, Ananias A. Escalante

Research output: Contribution to journalArticle

Abstract

The study of the three protagonists in malaria-the Plasmodium parasite, the Anopheles mosquito, and the human host-is key to developing methods to control and eventually eliminate the disease. Genomic technologies, including the recent development of next-generation sequencing, enable interrogation of this triangle to an unprecedented level of scrutiny, and promise exciting progress toward real-time epidemiology studies and the study of evolutionary adaptation. We discuss the use of genomics by the International Centers of Excellence for Malaria Research, a network of field sites and laboratories in malaria-endemic countries that undertake cutting-edge research, training, and technology transfer in malarious countries of the world.

Original languageEnglish (US)
Pages (from-to)87-98
Number of pages12
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume93
Issue number3
DOIs
StatePublished - Sep 1 2015

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Population Genetics
Genomics
Malaria
Plasmodium malariae
Genome
Technology Transfer
Anopheles
Culicidae
Research
Parasites
Epidemiology
Technology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria : A View Across the International Centers of Excellence for Malaria Research. / Carlton, Jane M.; Volkman, Sarah K.; Uplekar, Swapna; Hupalo, Daniel N.; Pereira Alves, João Marcelo; Cui, Liwang; Donnelly, Martin; Roos, David S.; Harb, Omar S.; Acosta, Monica; Read, Andrew; Ribolla, Paulo E M; Singh, Om P.; Valecha, Neena; Wassmer, Samuel C.; Ferreira, Marcelo; Escalante, Ananias A.

In: American Journal of Tropical Medicine and Hygiene, Vol. 93, No. 3, 01.09.2015, p. 87-98.

Research output: Contribution to journalArticle

Carlton, JM, Volkman, SK, Uplekar, S, Hupalo, DN, Pereira Alves, JM, Cui, L, Donnelly, M, Roos, DS, Harb, OS, Acosta, M, Read, A, Ribolla, PEM, Singh, OP, Valecha, N, Wassmer, SC, Ferreira, M & Escalante, AA 2015, 'Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research', American Journal of Tropical Medicine and Hygiene, vol. 93, no. 3, pp. 87-98. https://doi.org/10.4269/ajtmh.15-0049
Carlton, Jane M. ; Volkman, Sarah K. ; Uplekar, Swapna ; Hupalo, Daniel N. ; Pereira Alves, João Marcelo ; Cui, Liwang ; Donnelly, Martin ; Roos, David S. ; Harb, Omar S. ; Acosta, Monica ; Read, Andrew ; Ribolla, Paulo E M ; Singh, Om P. ; Valecha, Neena ; Wassmer, Samuel C. ; Ferreira, Marcelo ; Escalante, Ananias A. / Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria : A View Across the International Centers of Excellence for Malaria Research. In: American Journal of Tropical Medicine and Hygiene. 2015 ; Vol. 93, No. 3. pp. 87-98.
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