Polysomnographic investigation of sleep and respiratory parameters in women with temporomandibular pain disorders

Boris Dubrovsky, Karen Raphael, Gilles J. Lavigne, Malvin N. Janal, David Sirois, Pia E. Wigren, Lena V. Nemelivsky, Jack J. Klausner, Ana C. Krieger

Research output: Contribution to journalArticle

Abstract

Study Objectives: Temporomandibular pain disorders (TMD) and myofascial pain were linked to increased prevalence of insomnia and obstructive sleep apnea (OSA) on clinical grounds. However, the literature lacks an accurate polysomnographic (PSG) characterization of sleep abnormalities associated with TMD, given that prior studies included small or uncontrolled samples of TMD patients. The present investigation aims to objectively evaluate measures of sleep and respiratory disturbance in a large representative sample of TMD cases in comparison with matched controls. Methods: Sleep, respiration, and limb movements were measured using a 2-night attended PSG protocol in 170 women - 124 TMD cases with myofascial pain and 46 demographically matched controls. The second night data were compared between the groups using ANCOVAs. In TMD cases, the relationship between pain ratings and sleep parameters was analyzed using multiple regressions. Results: In comparison to healthy controls, TMD cased evidenced a significant increase in stage N1 sleep (12.2% ± 7.6% vs. 9.2% ± 5.0%, p = 0.03), which was only mild relative to normative values. TMD cases also demonstrated mild but significant elevations in arousals associated with all types of respiratory events (6.0/h ± 6.1 vs. 3.5/h ± 3.3 p = 0.02) and in respiratory effort related arousals (RERAs, 4.3/h ± 4.3 vs. 2.6/h ± 2.7, p = 0.02). Myofascial pain predicted a lower sleep efficiency (p = 0.01), more frequent awakenings (p = 0.04), and higher RERA index (p = 0.04) among TMD cases. Conclusions: Myofascial pain in TMD is associated with mild elevation in sleep fragmentation and increased frequency of RERA events. Further research is required to evaluate the clinical significance of these findings.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalJournal of Clinical Sleep Medicine
Volume10
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Temporomandibular Joint Disorders
Somatoform Disorders
Sleep
Pain
Arousal
Sleep Deprivation
Sleep Stages
Sleep Initiation and Maintenance Disorders
Obstructive Sleep Apnea
Respiration
Extremities

Keywords

  • Myofascial pain
  • Respiratory effort related arousals
  • Sleep disturbance
  • Temporomandibular disorders
  • Upper airway resistance

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Polysomnographic investigation of sleep and respiratory parameters in women with temporomandibular pain disorders. / Dubrovsky, Boris; Raphael, Karen; Lavigne, Gilles J.; Janal, Malvin N.; Sirois, David; Wigren, Pia E.; Nemelivsky, Lena V.; Klausner, Jack J.; Krieger, Ana C.

In: Journal of Clinical Sleep Medicine, Vol. 10, No. 2, 2014, p. 195-201.

Research output: Contribution to journalArticle

Dubrovsky, Boris ; Raphael, Karen ; Lavigne, Gilles J. ; Janal, Malvin N. ; Sirois, David ; Wigren, Pia E. ; Nemelivsky, Lena V. ; Klausner, Jack J. ; Krieger, Ana C. / Polysomnographic investigation of sleep and respiratory parameters in women with temporomandibular pain disorders. In: Journal of Clinical Sleep Medicine. 2014 ; Vol. 10, No. 2. pp. 195-201.
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abstract = "Study Objectives: Temporomandibular pain disorders (TMD) and myofascial pain were linked to increased prevalence of insomnia and obstructive sleep apnea (OSA) on clinical grounds. However, the literature lacks an accurate polysomnographic (PSG) characterization of sleep abnormalities associated with TMD, given that prior studies included small or uncontrolled samples of TMD patients. The present investigation aims to objectively evaluate measures of sleep and respiratory disturbance in a large representative sample of TMD cases in comparison with matched controls. Methods: Sleep, respiration, and limb movements were measured using a 2-night attended PSG protocol in 170 women - 124 TMD cases with myofascial pain and 46 demographically matched controls. The second night data were compared between the groups using ANCOVAs. In TMD cases, the relationship between pain ratings and sleep parameters was analyzed using multiple regressions. Results: In comparison to healthy controls, TMD cased evidenced a significant increase in stage N1 sleep (12.2{\%} ± 7.6{\%} vs. 9.2{\%} ± 5.0{\%}, p = 0.03), which was only mild relative to normative values. TMD cases also demonstrated mild but significant elevations in arousals associated with all types of respiratory events (6.0/h ± 6.1 vs. 3.5/h ± 3.3 p = 0.02) and in respiratory effort related arousals (RERAs, 4.3/h ± 4.3 vs. 2.6/h ± 2.7, p = 0.02). Myofascial pain predicted a lower sleep efficiency (p = 0.01), more frequent awakenings (p = 0.04), and higher RERA index (p = 0.04) among TMD cases. Conclusions: Myofascial pain in TMD is associated with mild elevation in sleep fragmentation and increased frequency of RERA events. Further research is required to evaluate the clinical significance of these findings.",
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AU - Dubrovsky, Boris

AU - Raphael, Karen

AU - Lavigne, Gilles J.

AU - Janal, Malvin N.

AU - Sirois, David

AU - Wigren, Pia E.

AU - Nemelivsky, Lena V.

AU - Klausner, Jack J.

AU - Krieger, Ana C.

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KW - Temporomandibular disorders

KW - Upper airway resistance

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