Polymorphs, proteins, and nucleation theory: A critical analysis

Research output: Contribution to journalArticle

Abstract

Over the last eight years newtheories regarding nucleation, crystal growth, and polymorphism have emerged. Many of these theories were developed in response to observations in nature, where classical nucleation theory failed to account for amorphous mineral precursors, phases, and particle assembly processes that are responsible for the formation of invertebrate mineralized skeletal elements, such as the mollusk shell nacre layer (aragonite polymorph) and the sea urchin spicule (calcite polymorph). Here, we summarize these existing nucleation theories and place them within the context of what we know about biomineralization proteins, which are likely participants in the management of mineral precursor formation, stabilization, and assembly into polymorphs. With few exceptions, much of the protein literature confirms that polymorph-specific proteins, such as those from mollusk shell nacre aragonite, can promote polymorph formation. However, past studies fail to provide important mechanistic insights into this process, owing to variations in techniques, methodologies, and the lack of standardization in mineral assay experimentation. We propose that the way forward past this roadblock is for the protein community to adopt standardized nucleation assays and approaches that are compatible with current and emerging nucleation precursor studies. This will allow cross-comparisons, kinetic observations, and hopefully provide the information that will explain how proteins manage polymorph formation and stabilization.

Original languageEnglish (US)
Article number62
JournalMinerals
Volume7
Issue number4
DOIs
StatePublished - Apr 21 2017

Fingerprint

critical analysis
Polymorphism
nucleation
Nucleation
Proteins
protein
aragonite
Minerals
stabilization
mineral
assay
shell
biomineralization
Assays
spicule
Stabilization
standardization
Biomineralization
polymorphism
Calcite

Keywords

  • Aragonite
  • Biomineralization
  • Calcite
  • Classical nucleation theory
  • Crystallization by particle attachment
  • Mollusk
  • Non-classical nucleation
  • Polymorphs
  • Proteins
  • Sea urchin
  • Vaterite

ASJC Scopus subject areas

  • Geotechnical Engineering and Engineering Geology
  • Geology

Cite this

Polymorphs, proteins, and nucleation theory : A critical analysis. / Evans, John.

In: Minerals, Vol. 7, No. 4, 62, 21.04.2017.

Research output: Contribution to journalArticle

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