Polarimetric imaging of amyloid

Werner Kaminksy, Lee Way Jin, Steven Powell, Izumi Maezawa, Kacey Claborn, Charles Branham, Bart Kahr

Research output: Contribution to journalReview article

Abstract

New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures.

Original languageEnglish (US)
Pages (from-to)324-338
Number of pages15
JournalMicron
Volume37
Issue number4
DOIs
StatePublished - Jun 1 2006

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Keywords

  • Alzheimer's disease
  • Amyloidosis
  • Circular dichroism
  • Circular extinction
  • Congo red
  • Linear birefringence
  • Linear dichroism

ASJC Scopus subject areas

  • Structural Biology
  • Materials Science(all)
  • Physics and Astronomy(all)
  • Cell Biology

Cite this

Kaminksy, W., Jin, L. W., Powell, S., Maezawa, I., Claborn, K., Branham, C., & Kahr, B. (2006). Polarimetric imaging of amyloid. Micron, 37(4), 324-338. https://doi.org/10.1016/j.micron.2005.10.014