Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group

Kevin R. King, Luanda P. Grazette, Dina N. Paltoo, John McDevitt, Samuel K. Sia, Paddy M. Barrett, Fred S. Apple, Paul A. Gurbel, Ralph Weissleder, Hilary Leeds, Erin J. Iturriaga, Anupama K. Rao, Bishow Adhikari, Patrice Desvigne-Nickens, Zorina S. Galis, Peter Libby

Research output: Contribution to journalReview article

Abstract

Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalJACC: Basic to Translational Science
Volume1
Issue number1-2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Point-of-Care Systems
National Heart, Lung, and Blood Institute (U.S.)
Equipment Design
Precision Medicine
Needs Assessment
Health Personnel
Patient Care
Biomarkers
Medicine
Technology
Equipment and Supplies
Research

Keywords

  • biomarkers
  • clinical trials
  • precision medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research : National Heart, Lung, and Blood Institute Working Group. / King, Kevin R.; Grazette, Luanda P.; Paltoo, Dina N.; McDevitt, John; Sia, Samuel K.; Barrett, Paddy M.; Apple, Fred S.; Gurbel, Paul A.; Weissleder, Ralph; Leeds, Hilary; Iturriaga, Erin J.; Rao, Anupama K.; Adhikari, Bishow; Desvigne-Nickens, Patrice; Galis, Zorina S.; Libby, Peter.

In: JACC: Basic to Translational Science, Vol. 1, No. 1-2, 01.02.2016, p. 73-86.

Research output: Contribution to journalReview article

King, KR, Grazette, LP, Paltoo, DN, McDevitt, J, Sia, SK, Barrett, PM, Apple, FS, Gurbel, PA, Weissleder, R, Leeds, H, Iturriaga, EJ, Rao, AK, Adhikari, B, Desvigne-Nickens, P, Galis, ZS & Libby, P 2016, 'Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group', JACC: Basic to Translational Science, vol. 1, no. 1-2, pp. 73-86. https://doi.org/10.1016/j.jacbts.2016.01.008
King, Kevin R. ; Grazette, Luanda P. ; Paltoo, Dina N. ; McDevitt, John ; Sia, Samuel K. ; Barrett, Paddy M. ; Apple, Fred S. ; Gurbel, Paul A. ; Weissleder, Ralph ; Leeds, Hilary ; Iturriaga, Erin J. ; Rao, Anupama K. ; Adhikari, Bishow ; Desvigne-Nickens, Patrice ; Galis, Zorina S. ; Libby, Peter. / Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research : National Heart, Lung, and Blood Institute Working Group. In: JACC: Basic to Translational Science. 2016 ; Vol. 1, No. 1-2. pp. 73-86.
@article{7bc707f077e94a70b60aaca2e7e5782f,
title = "Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group",
abstract = "Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.",
keywords = "biomarkers, clinical trials, precision medicine",
author = "King, {Kevin R.} and Grazette, {Luanda P.} and Paltoo, {Dina N.} and John McDevitt and Sia, {Samuel K.} and Barrett, {Paddy M.} and Apple, {Fred S.} and Gurbel, {Paul A.} and Ralph Weissleder and Hilary Leeds and Iturriaga, {Erin J.} and Rao, {Anupama K.} and Bishow Adhikari and Patrice Desvigne-Nickens and Galis, {Zorina S.} and Peter Libby",
year = "2016",
month = "2",
day = "1",
doi = "10.1016/j.jacbts.2016.01.008",
language = "English (US)",
volume = "1",
pages = "73--86",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier Inc.",
number = "1-2",

}

TY - JOUR

T1 - Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research

T2 - National Heart, Lung, and Blood Institute Working Group

AU - King, Kevin R.

AU - Grazette, Luanda P.

AU - Paltoo, Dina N.

AU - McDevitt, John

AU - Sia, Samuel K.

AU - Barrett, Paddy M.

AU - Apple, Fred S.

AU - Gurbel, Paul A.

AU - Weissleder, Ralph

AU - Leeds, Hilary

AU - Iturriaga, Erin J.

AU - Rao, Anupama K.

AU - Adhikari, Bishow

AU - Desvigne-Nickens, Patrice

AU - Galis, Zorina S.

AU - Libby, Peter

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.

AB - Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.

KW - biomarkers

KW - clinical trials

KW - precision medicine

UR - http://www.scopus.com/inward/record.url?scp=85010424124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010424124&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2016.01.008

DO - 10.1016/j.jacbts.2016.01.008

M3 - Review article

VL - 1

SP - 73

EP - 86

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 1-2

ER -