Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade

Shin Ichiro Tachibana, Steven A. Sullivan, Satoru Kawai, Shota Nakamura, Hyunjae R. Kim, Naohisa Goto, Nobuko Arisue, Nirianne M Q Palacpac, Hajime Honma, Masanori Yagi, Takahiro Tougan, Yuko Katakai, Osamu Kaneko, Toshihiro Mita, Kiyoshi Kita, Yasuhiro Yasutomi, Patrick L. Sutton, Rimma Shakhbatyan, Toshihiro Horii, Teruo Yasunaga & 4 others John W. Barnwell, Ananias A. Escalante, Jane M. Carlton, Kazuyuki Tanabe

Research output: Contribution to journalArticle

Abstract

P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax.

Original languageEnglish (US)
Pages (from-to)1051-1055
Number of pages5
JournalNature Genetics
Volume44
Issue number9
DOIs
StatePublished - Sep 2012

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Plasmodium cynomolgi
Vivax Malaria
Plasmodium vivax
Haplorhini
Genome
Parasites
Malaria
Plasmodium knowlesi
Cercopithecidae
Multigene Family
Microsatellite Repeats
Single Nucleotide Polymorphism
Immune System
Erythrocytes

ASJC Scopus subject areas

  • Genetics

Cite this

Tachibana, S. I., Sullivan, S. A., Kawai, S., Nakamura, S., Kim, H. R., Goto, N., ... Tanabe, K. (2012). Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nature Genetics, 44(9), 1051-1055. https://doi.org/10.1038/ng.2375

Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. / Tachibana, Shin Ichiro; Sullivan, Steven A.; Kawai, Satoru; Nakamura, Shota; Kim, Hyunjae R.; Goto, Naohisa; Arisue, Nobuko; Palacpac, Nirianne M Q; Honma, Hajime; Yagi, Masanori; Tougan, Takahiro; Katakai, Yuko; Kaneko, Osamu; Mita, Toshihiro; Kita, Kiyoshi; Yasutomi, Yasuhiro; Sutton, Patrick L.; Shakhbatyan, Rimma; Horii, Toshihiro; Yasunaga, Teruo; Barnwell, John W.; Escalante, Ananias A.; Carlton, Jane M.; Tanabe, Kazuyuki.

In: Nature Genetics, Vol. 44, No. 9, 09.2012, p. 1051-1055.

Research output: Contribution to journalArticle

Tachibana, SI, Sullivan, SA, Kawai, S, Nakamura, S, Kim, HR, Goto, N, Arisue, N, Palacpac, NMQ, Honma, H, Yagi, M, Tougan, T, Katakai, Y, Kaneko, O, Mita, T, Kita, K, Yasutomi, Y, Sutton, PL, Shakhbatyan, R, Horii, T, Yasunaga, T, Barnwell, JW, Escalante, AA, Carlton, JM & Tanabe, K 2012, 'Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade', Nature Genetics, vol. 44, no. 9, pp. 1051-1055. https://doi.org/10.1038/ng.2375
Tachibana SI, Sullivan SA, Kawai S, Nakamura S, Kim HR, Goto N et al. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nature Genetics. 2012 Sep;44(9):1051-1055. https://doi.org/10.1038/ng.2375
Tachibana, Shin Ichiro ; Sullivan, Steven A. ; Kawai, Satoru ; Nakamura, Shota ; Kim, Hyunjae R. ; Goto, Naohisa ; Arisue, Nobuko ; Palacpac, Nirianne M Q ; Honma, Hajime ; Yagi, Masanori ; Tougan, Takahiro ; Katakai, Yuko ; Kaneko, Osamu ; Mita, Toshihiro ; Kita, Kiyoshi ; Yasutomi, Yasuhiro ; Sutton, Patrick L. ; Shakhbatyan, Rimma ; Horii, Toshihiro ; Yasunaga, Teruo ; Barnwell, John W. ; Escalante, Ananias A. ; Carlton, Jane M. ; Tanabe, Kazuyuki. / Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. In: Nature Genetics. 2012 ; Vol. 44, No. 9. pp. 1051-1055.
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