Placental characteristics and birthweight

Carolyn M. Salafia, Jun Zhang, Adrian K. Charles, Michaeline Bresnahan, Patrick Shrout, Wenyu Sun, Elizabeth M. Maas

Research output: Contribution to journalArticle

Abstract

Standard gross placental measures capture dimensions relevant to specific placental functions. Our objective was to determine their accountability independent of placental weight for variance in birthweight, an important proxy for intrauterine 'adequacy' in fetal origins studies. The sample consisted of 24 152 singleton liveborn children of the Collaborative Perinatal Project delivered from 34 to 42 completed weeks gestation, with complete data for six placental measures (placental disc shape, umbilical cord length, distance from cord insertion to nearest margin, large diameter, small diameter, placental thickness) and placental weight. Associations between birthweight and placental measures were examined using multiple linear regression. Placental weight alone accounted for 36.6% of birthweight variation; the six other placental measures accounted for 28.1%. Combined, all placental measures accounted for 39.1% of birthweight variation. Seven maternal characteristics (age, height, weight, parity, socio-economic status, cigarette use, and race) were investigated to determine whether their known associations with birthweight were mediated by placental markers. Analysis suggested that the impact of all maternal characteristics except smoking was consistent with mediation by placental characteristics.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalPaediatric and Perinatal Epidemiology
Volume22
Issue number3
DOIs
StatePublished - May 2008

Fingerprint

Weights and Measures
Umbilical Cord
Social Responsibility
Maternal Age
Proxy
Parity
Tobacco Products
Linear Models
Smoking
Economics
Mothers
Pregnancy

Keywords

  • Birthweight
  • Collaborative Perinatal Project
  • Placenta
  • Placental characteristics
  • Placental weight

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health

Cite this

Salafia, C. M., Zhang, J., Charles, A. K., Bresnahan, M., Shrout, P., Sun, W., & Maas, E. M. (2008). Placental characteristics and birthweight. Paediatric and Perinatal Epidemiology, 22(3), 229-239. https://doi.org/10.1111/j.1365-3016.2008.00935.x

Placental characteristics and birthweight. / Salafia, Carolyn M.; Zhang, Jun; Charles, Adrian K.; Bresnahan, Michaeline; Shrout, Patrick; Sun, Wenyu; Maas, Elizabeth M.

In: Paediatric and Perinatal Epidemiology, Vol. 22, No. 3, 05.2008, p. 229-239.

Research output: Contribution to journalArticle

Salafia, CM, Zhang, J, Charles, AK, Bresnahan, M, Shrout, P, Sun, W & Maas, EM 2008, 'Placental characteristics and birthweight', Paediatric and Perinatal Epidemiology, vol. 22, no. 3, pp. 229-239. https://doi.org/10.1111/j.1365-3016.2008.00935.x
Salafia, Carolyn M. ; Zhang, Jun ; Charles, Adrian K. ; Bresnahan, Michaeline ; Shrout, Patrick ; Sun, Wenyu ; Maas, Elizabeth M. / Placental characteristics and birthweight. In: Paediatric and Perinatal Epidemiology. 2008 ; Vol. 22, No. 3. pp. 229-239.
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