Abstract
Dietary approaches to cancer chemoprevention increasingly have focused on single nutrients or phytochemicals to stimulate one or another enzymatic metabolizing system. These procedures, which aim to boost carcinogen detoxification or inhibit carcinogen bioactivation, fail to take into account the multiple and paradoxical biological outcomes of enzyme modulators that make their effects unpredictable. Here, we critically examine the scientific and medical evidence for the idea that the physiological roles of specific enzymes may be manipulated by regular, long-term administration of isolated nutrients and other chemicals derived from food plants. Instead, we argue that consumption of healthful diets is most likely to reduce mutagenesis and cancer risk, and that research efforts and dietary recommendations should be redirected away from single nutrients to emphasize the improvement of dietary patterns as a principal strategy for public health policy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-189 |
| Number of pages | 9 |
| Journal | Mutation Research - Reviews in Mutation Research |
| Volume | 543 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2003 |
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Keywords
- Cancer
- Chemoprevention
- Dietary patterns
- Metabolizing enzymes
- Mutagenesis
- Phytochemicals
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
Cite this
Pitfalls of enzyme-based molecular anticancer dietary manipulations : Food for thought. / Paolini, Moreno; Nestle, Marion.
In: Mutation Research - Reviews in Mutation Research, Vol. 543, No. 3, 06.2003, p. 181-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pitfalls of enzyme-based molecular anticancer dietary manipulations
T2 - Food for thought
AU - Paolini, Moreno
AU - Nestle, Marion
PY - 2003/6
Y1 - 2003/6
N2 - Dietary approaches to cancer chemoprevention increasingly have focused on single nutrients or phytochemicals to stimulate one or another enzymatic metabolizing system. These procedures, which aim to boost carcinogen detoxification or inhibit carcinogen bioactivation, fail to take into account the multiple and paradoxical biological outcomes of enzyme modulators that make their effects unpredictable. Here, we critically examine the scientific and medical evidence for the idea that the physiological roles of specific enzymes may be manipulated by regular, long-term administration of isolated nutrients and other chemicals derived from food plants. Instead, we argue that consumption of healthful diets is most likely to reduce mutagenesis and cancer risk, and that research efforts and dietary recommendations should be redirected away from single nutrients to emphasize the improvement of dietary patterns as a principal strategy for public health policy.
AB - Dietary approaches to cancer chemoprevention increasingly have focused on single nutrients or phytochemicals to stimulate one or another enzymatic metabolizing system. These procedures, which aim to boost carcinogen detoxification or inhibit carcinogen bioactivation, fail to take into account the multiple and paradoxical biological outcomes of enzyme modulators that make their effects unpredictable. Here, we critically examine the scientific and medical evidence for the idea that the physiological roles of specific enzymes may be manipulated by regular, long-term administration of isolated nutrients and other chemicals derived from food plants. Instead, we argue that consumption of healthful diets is most likely to reduce mutagenesis and cancer risk, and that research efforts and dietary recommendations should be redirected away from single nutrients to emphasize the improvement of dietary patterns as a principal strategy for public health policy.
KW - Cancer
KW - Chemoprevention
KW - Dietary patterns
KW - Metabolizing enzymes
KW - Mutagenesis
KW - Phytochemicals
UR - http://www.scopus.com/inward/record.url?scp=0038350661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038350661&partnerID=8YFLogxK
U2 - 10.1016/S1383-5742(02)00092-3
DO - 10.1016/S1383-5742(02)00092-3
M3 - Article
C2 - 12787810
AN - SCOPUS:0038350661
VL - 543
SP - 181
EP - 189
JO - Mutation Research - Reviews in Mutation Research
JF - Mutation Research - Reviews in Mutation Research
SN - 1383-5742
IS - 3
ER -