Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus

Thomas Marissal, Paolo Bonifazi, Michel Aimé Picardo, Romain Nardou, Ludovic Franck Petit, Agnès Baude, Gordon Fishell, Yehezkel Ben-Ari, Rosa Cossart

Research output: Contribution to journalArticle

Abstract

The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early postnatal stages is minimal. However, without fast GABAergic transmission, a different situation may prevail. In the adult CA3, blocking fast GABAergic transmission induces the generation of network bursts that can be triggered by the stimulation of single pyramidal neurons. Here we revisit the network function of CA3 glutamatergic neurons from a developmental viewpoint, without fast GABAergic transmission. We uncover a sub-population of early-generated glutamatergic neurons that impacts network dynamics when stimulated in the juvenile hippocampus. Additionally, this population displays characteristic morpho-physiological features in the juvenile and adult hippocampus. Therefore, the apparently homogeneous glutamatergic cell population likely displays a morpho-functional diversity rooted in temporal embryonic origins.

Original languageEnglish (US)
Article number2318
JournalNature Communications
Volume3
DOIs
StatePublished - Dec 1 2012

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hippocampus
neurons
Neurons
Hippocampus
cells
Population
hubs
synchronism
Physiological Phenomena
Synchronization
Pyramidal Cells
Population Characteristics
stimulation
bursts
Cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Marissal, T., Bonifazi, P., Picardo, M. A., Nardou, R., Petit, L. F., Baude, A., ... Cossart, R. (2012). Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus. Nature Communications, 3, [2318]. https://doi.org/10.1038/ncomms2318

Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus. / Marissal, Thomas; Bonifazi, Paolo; Picardo, Michel Aimé; Nardou, Romain; Petit, Ludovic Franck; Baude, Agnès; Fishell, Gordon; Ben-Ari, Yehezkel; Cossart, Rosa.

In: Nature Communications, Vol. 3, 2318, 01.12.2012.

Research output: Contribution to journalArticle

Marissal, T, Bonifazi, P, Picardo, MA, Nardou, R, Petit, LF, Baude, A, Fishell, G, Ben-Ari, Y & Cossart, R 2012, 'Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus', Nature Communications, vol. 3, 2318. https://doi.org/10.1038/ncomms2318
Marissal, Thomas ; Bonifazi, Paolo ; Picardo, Michel Aimé ; Nardou, Romain ; Petit, Ludovic Franck ; Baude, Agnès ; Fishell, Gordon ; Ben-Ari, Yehezkel ; Cossart, Rosa. / Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus. In: Nature Communications. 2012 ; Vol. 3.
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