Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus

Michel Aimé Picardo, Philippe Guigue, Paolo Bonifazi, Renata Batista-Brito, Camille Allene, Alain Ribas, Gordon Fishell, Agnès Baude, Rosa Cossart

Research output: Contribution to journalArticle

Abstract

Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is supported by a subpopulation of GABA neurons. However, it is unclear whether hub cells are only transiently present or later develop into distinctive subclasses of interneurons. These questions are difficult to assess given the heterogeneity of the GABA neurons and the poor early expression of markers. To circumvent this conundrum, we used "genetic fate mapping" that allows for the selective labeling of GABA neurons based on their place and time of origin. We show that early-generated GABA cells form a subpopulation of hub neurons, characterized by an exceptionally widespread axonal arborization and the ability to single-handedly impact network dynamics when stimulated. Pioneer hub neurons remain into adulthood, when they acquire the classical markers of long-range projecting GABA neurons. Video Abstract:

Original languageEnglish (US)
Pages (from-to)695-709
Number of pages15
JournalNeuron
Volume71
Issue number4
DOIs
StatePublished - Aug 25 2011

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GABAergic Neurons
Hippocampus
Neurons
Interneurons

ASJC Scopus subject areas

  • Neuroscience(all)

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Picardo, M. A., Guigue, P., Bonifazi, P., Batista-Brito, R., Allene, C., Ribas, A., ... Cossart, R. (2011). Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus. Neuron, 71(4), 695-709. https://doi.org/10.1016/j.neuron.2011.06.018

Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus. / Picardo, Michel Aimé; Guigue, Philippe; Bonifazi, Paolo; Batista-Brito, Renata; Allene, Camille; Ribas, Alain; Fishell, Gordon; Baude, Agnès; Cossart, Rosa.

In: Neuron, Vol. 71, No. 4, 25.08.2011, p. 695-709.

Research output: Contribution to journalArticle

Picardo, MA, Guigue, P, Bonifazi, P, Batista-Brito, R, Allene, C, Ribas, A, Fishell, G, Baude, A & Cossart, R 2011, 'Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus', Neuron, vol. 71, no. 4, pp. 695-709. https://doi.org/10.1016/j.neuron.2011.06.018
Picardo MA, Guigue P, Bonifazi P, Batista-Brito R, Allene C, Ribas A et al. Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus. Neuron. 2011 Aug 25;71(4):695-709. https://doi.org/10.1016/j.neuron.2011.06.018
Picardo, Michel Aimé ; Guigue, Philippe ; Bonifazi, Paolo ; Batista-Brito, Renata ; Allene, Camille ; Ribas, Alain ; Fishell, Gordon ; Baude, Agnès ; Cossart, Rosa. / Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus. In: Neuron. 2011 ; Vol. 71, No. 4. pp. 695-709.
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