Pilot study: digital subtraction radiography as a tool to assess alveolar bone changes in periodontitis patients under treatment with subantimicrobial doses of doxycycline

Arthur D. Goren, Stanley M. Dunn, Mark Wolff, Paul F. van der Stelt, Dan C. Colosi, Lorne M. Golub

Research output: Contribution to journalArticle

Abstract

Background: Subtle changes in marginal alveolar bone level can be demonstrated using digital subtraction of sequential radiographs. Objective: We aimed to evaluate the practical application of geometrically corrected digital subtraction in a clinical study of alveolar bone response to a drug previously shown to inhibit alveolar bone loss. Study design: Selected periapical radiographs were acquired with projective standardization of patients with clinical marginal alveolar bone loss. Subsequently, patients received a 6-month regimen of subantimicrobial doxycycline or placebo. Standardized radiographs of the same alveolar regions were acquired after 3 and 6 months, and baseline radiographs were subtracted from these images. Results: Blinded digital subtraction analysis indicated various levels of marginal bone gain in 3 of the 6 patients in the experimental group, whereas in 3 of the 5 placebo patients the method showed bone loss. Conclusion: These results suggest that geometrically corrected digital subtraction possibly agrees with clinical predictors of bone loss severity.

Original languageEnglish (US)
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume106
Issue number4
DOIs
StatePublished - Oct 2008

Fingerprint

Radiographic Image Enhancement
Doxycycline
Periodontitis
Bone and Bones
Alveolar Bone Loss
Placebos
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Dentistry(all)
  • Oral Surgery

Cite this

Pilot study : digital subtraction radiography as a tool to assess alveolar bone changes in periodontitis patients under treatment with subantimicrobial doses of doxycycline. / Goren, Arthur D.; Dunn, Stanley M.; Wolff, Mark; van der Stelt, Paul F.; Colosi, Dan C.; Golub, Lorne M.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 106, No. 4, 10.2008.

Research output: Contribution to journalArticle

@article{dad2eced1ac346069331c57f503364d6,
title = "Pilot study: digital subtraction radiography as a tool to assess alveolar bone changes in periodontitis patients under treatment with subantimicrobial doses of doxycycline",
abstract = "Background: Subtle changes in marginal alveolar bone level can be demonstrated using digital subtraction of sequential radiographs. Objective: We aimed to evaluate the practical application of geometrically corrected digital subtraction in a clinical study of alveolar bone response to a drug previously shown to inhibit alveolar bone loss. Study design: Selected periapical radiographs were acquired with projective standardization of patients with clinical marginal alveolar bone loss. Subsequently, patients received a 6-month regimen of subantimicrobial doxycycline or placebo. Standardized radiographs of the same alveolar regions were acquired after 3 and 6 months, and baseline radiographs were subtracted from these images. Results: Blinded digital subtraction analysis indicated various levels of marginal bone gain in 3 of the 6 patients in the experimental group, whereas in 3 of the 5 placebo patients the method showed bone loss. Conclusion: These results suggest that geometrically corrected digital subtraction possibly agrees with clinical predictors of bone loss severity.",
author = "Goren, {Arthur D.} and Dunn, {Stanley M.} and Mark Wolff and {van der Stelt}, {Paul F.} and Colosi, {Dan C.} and Golub, {Lorne M.}",
year = "2008",
month = "10",
doi = "10.1016/j.tripleo.2008.06.010",
language = "English (US)",
volume = "106",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Pilot study

T2 - digital subtraction radiography as a tool to assess alveolar bone changes in periodontitis patients under treatment with subantimicrobial doses of doxycycline

AU - Goren, Arthur D.

AU - Dunn, Stanley M.

AU - Wolff, Mark

AU - van der Stelt, Paul F.

AU - Colosi, Dan C.

AU - Golub, Lorne M.

PY - 2008/10

Y1 - 2008/10

N2 - Background: Subtle changes in marginal alveolar bone level can be demonstrated using digital subtraction of sequential radiographs. Objective: We aimed to evaluate the practical application of geometrically corrected digital subtraction in a clinical study of alveolar bone response to a drug previously shown to inhibit alveolar bone loss. Study design: Selected periapical radiographs were acquired with projective standardization of patients with clinical marginal alveolar bone loss. Subsequently, patients received a 6-month regimen of subantimicrobial doxycycline or placebo. Standardized radiographs of the same alveolar regions were acquired after 3 and 6 months, and baseline radiographs were subtracted from these images. Results: Blinded digital subtraction analysis indicated various levels of marginal bone gain in 3 of the 6 patients in the experimental group, whereas in 3 of the 5 placebo patients the method showed bone loss. Conclusion: These results suggest that geometrically corrected digital subtraction possibly agrees with clinical predictors of bone loss severity.

AB - Background: Subtle changes in marginal alveolar bone level can be demonstrated using digital subtraction of sequential radiographs. Objective: We aimed to evaluate the practical application of geometrically corrected digital subtraction in a clinical study of alveolar bone response to a drug previously shown to inhibit alveolar bone loss. Study design: Selected periapical radiographs were acquired with projective standardization of patients with clinical marginal alveolar bone loss. Subsequently, patients received a 6-month regimen of subantimicrobial doxycycline or placebo. Standardized radiographs of the same alveolar regions were acquired after 3 and 6 months, and baseline radiographs were subtracted from these images. Results: Blinded digital subtraction analysis indicated various levels of marginal bone gain in 3 of the 6 patients in the experimental group, whereas in 3 of the 5 placebo patients the method showed bone loss. Conclusion: These results suggest that geometrically corrected digital subtraction possibly agrees with clinical predictors of bone loss severity.

UR - http://www.scopus.com/inward/record.url?scp=55049094500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55049094500&partnerID=8YFLogxK

U2 - 10.1016/j.tripleo.2008.06.010

DO - 10.1016/j.tripleo.2008.06.010

M3 - Article

C2 - 18718780

AN - SCOPUS:55049094500

VL - 106

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 4

ER -