Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors

Goichi Miyoshi, Simon J.B. Butt, Hirohide Takebayashi, Gordon Fishell

Research output: Contribution to journalArticle

Abstract

Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

Original languageEnglish (US)
Pages (from-to)7786-7798
Number of pages13
JournalJournal of Neuroscience
Volume27
Issue number29
DOIs
StatePublished - Jul 18 2007

Fingerprint

Telencephalon
Interneurons
Median Eminence
Basic Helix-Loop-Helix Transcription Factors
Neocortex
Cerebral Cortex
Embryonic Structures
Neurons
Population

Keywords

  • Cortex
  • Electrophysiology
  • GABA
  • Genetics
  • Interneurons
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. / Miyoshi, Goichi; Butt, Simon J.B.; Takebayashi, Hirohide; Fishell, Gordon.

In: Journal of Neuroscience, Vol. 27, No. 29, 18.07.2007, p. 7786-7798.

Research output: Contribution to journalArticle

Miyoshi, Goichi ; Butt, Simon J.B. ; Takebayashi, Hirohide ; Fishell, Gordon. / Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 29. pp. 7786-7798.
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