Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors

Goichi Miyoshi, Simon J.B. Butt, Hirohide Takebayashi, Gordon Fishell

    Research output: Contribution to journalArticle

    Abstract

    Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

    Original languageEnglish (US)
    Pages (from-to)7786-7798
    Number of pages13
    JournalJournal of Neuroscience
    Volume27
    Issue number29
    DOIs
    StatePublished - Jul 18 2007

    Fingerprint

    Telencephalon
    Interneurons
    Median Eminence
    Basic Helix-Loop-Helix Transcription Factors
    Neocortex
    Cerebral Cortex
    Embryonic Structures
    Neurons
    Population

    Keywords

    • Cortex
    • Electrophysiology
    • GABA
    • Genetics
    • Interneurons
    • Transcription factor

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. / Miyoshi, Goichi; Butt, Simon J.B.; Takebayashi, Hirohide; Fishell, Gordon.

    In: Journal of Neuroscience, Vol. 27, No. 29, 18.07.2007, p. 7786-7798.

    Research output: Contribution to journalArticle

    Miyoshi, Goichi ; Butt, Simon J.B. ; Takebayashi, Hirohide ; Fishell, Gordon. / Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 29. pp. 7786-7798.
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