Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces

Paulo Coelho, Jack E. Lemons

Research output: Contribution to journalArticle

Abstract

The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Aluminablasted/ acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 5 30-50 nm and IBAD II = 5 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.

Original languageEnglish (US)
Pages (from-to)351-361
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume90
Issue number2
DOIs
StatePublished - Aug 2009

Fingerprint

Ion beam assisted deposition
Bioceramics
Aluminum Oxide
Alumina
Acids
Durapatite
Hydroxyapatite
X ray photoelectron spectroscopy
Plasmas
Coatings
Depth profiling
Secondary ion mass spectrometry
Stoichiometry
Ion beams
Energy dispersive spectroscopy
Bone
Torque
Scanning electron microscopy

Keywords

  • Animal model
  • Bioceramic
  • Biomechanical
  • Histomorphometric
  • Implant surface
  • Nanothickness
  • Surface characterization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

Cite this

@article{285ef5fdea7645d395e6f5999784a772,
title = "Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces",
abstract = "The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Aluminablasted/ acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 5 30-50 nm and IBAD II = 5 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.",
keywords = "Animal model, Bioceramic, Biomechanical, Histomorphometric, Implant surface, Nanothickness, Surface characterization",
author = "Paulo Coelho and Lemons, {Jack E.}",
year = "2009",
month = "8",
doi = "10.1002/jbm.a.32097",
language = "English (US)",
volume = "90",
pages = "351--361",
journal = "Journal of Biomedical Materials Research",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces

AU - Coelho, Paulo

AU - Lemons, Jack E.

PY - 2009/8

Y1 - 2009/8

N2 - The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Aluminablasted/ acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 5 30-50 nm and IBAD II = 5 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.

AB - The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Aluminablasted/ acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 5 30-50 nm and IBAD II = 5 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.

KW - Animal model

KW - Bioceramic

KW - Biomechanical

KW - Histomorphometric

KW - Implant surface

KW - Nanothickness

KW - Surface characterization

UR - http://www.scopus.com/inward/record.url?scp=67650497946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650497946&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.32097

DO - 10.1002/jbm.a.32097

M3 - Article

VL - 90

SP - 351

EP - 361

JO - Journal of Biomedical Materials Research

JF - Journal of Biomedical Materials Research

SN - 1549-3296

IS - 2

ER -