Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: A report from the childhood cancer survivor study

Todd A. Florin, G. Edgar Fryer, Thomas Miyoshi, Michael Weitzman, Ann C. Mertens, Melissa M. Hudson, Charles A. Sklar, Karen Emmons, Andrea Hinkle, John Whitton, Marilyn Stovall, Leslie L. Robison, Kevin C. Oeffinger

Research output: Contribution to journalArticle

Abstract

Purpose: To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors. Patients and Methods: Physical activity was assessed by self-report in 2,648 adult survivors of the Childhood Cancer Survivor Study. Participants in the Behavioral Risk Factor Surveillance System (BRFSS) survey administered through the Centers for Disease Control and Prevention (CDC) were used as a comparison group. Results: Survivors had a mean age of 28.7 years (range, 18.0-44.0 years) and were a mean of 23.1 years from their cancer diagnosis (range, 16.0-33.8 years). In multivariate models, ALL survivors were more likely to not meet CDC recommendations for physical activity [odds ratio (OR), 1.44; 95% confidence interval (95% CI), 1.32-1.57] and more likely to be inactive (OR, 1.74; 95% CI, 1.56-1.94) in comparison with the BRFSS general population. Survivors treated with >20-Gy cranial radiotherapy were at particular risk. Compared with BRFSS participants and adjusted for age, race, and ethnicity, survivors were more likely to not meet CDC recommendations (females: OR, 2.07, 95% CI, 1.67-2.56; males: OR, 1.43, 95% CI, 1.16-1.76) and more likely to be inactive (females: OR, 1.86; 95% CI, 1.50-2.31; males: OR, 1.84; 95% CI, 1.45-2.32). Conclusions: Long-term survivors of childhood ALL are less likely to meet physical activity recommendations and more likely to report no leisure-time physical activity in the past month. This level of inactivity likely further increases their risk of cardiovascular disease, osteoporosis, and all-cause mortality.

Original languageEnglish (US)
Pages (from-to)1356-1363
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2007

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survivors
Odds Ratio
Behavioral Risk Factor Surveillance System
Confidence Intervals
Neoplasms
Centers for Disease Control and Prevention (U.S.)
Exercise
Leisure Activities
Self Report
Population
Osteoporosis
Cardiovascular Diseases
Radiotherapy
Mortality

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia : A report from the childhood cancer survivor study. / Florin, Todd A.; Fryer, G. Edgar; Miyoshi, Thomas; Weitzman, Michael; Mertens, Ann C.; Hudson, Melissa M.; Sklar, Charles A.; Emmons, Karen; Hinkle, Andrea; Whitton, John; Stovall, Marilyn; Robison, Leslie L.; Oeffinger, Kevin C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 7, 01.07.2007, p. 1356-1363.

Research output: Contribution to journalArticle

Florin, TA, Fryer, GE, Miyoshi, T, Weitzman, M, Mertens, AC, Hudson, MM, Sklar, CA, Emmons, K, Hinkle, A, Whitton, J, Stovall, M, Robison, LL & Oeffinger, KC 2007, 'Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: A report from the childhood cancer survivor study', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 7, pp. 1356-1363. https://doi.org/10.1158/1055-9965.EPI-07-0048
Florin, Todd A. ; Fryer, G. Edgar ; Miyoshi, Thomas ; Weitzman, Michael ; Mertens, Ann C. ; Hudson, Melissa M. ; Sklar, Charles A. ; Emmons, Karen ; Hinkle, Andrea ; Whitton, John ; Stovall, Marilyn ; Robison, Leslie L. ; Oeffinger, Kevin C. / Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia : A report from the childhood cancer survivor study. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 7. pp. 1356-1363.
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abstract = "Purpose: To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors. Patients and Methods: Physical activity was assessed by self-report in 2,648 adult survivors of the Childhood Cancer Survivor Study. Participants in the Behavioral Risk Factor Surveillance System (BRFSS) survey administered through the Centers for Disease Control and Prevention (CDC) were used as a comparison group. Results: Survivors had a mean age of 28.7 years (range, 18.0-44.0 years) and were a mean of 23.1 years from their cancer diagnosis (range, 16.0-33.8 years). In multivariate models, ALL survivors were more likely to not meet CDC recommendations for physical activity [odds ratio (OR), 1.44; 95{\%} confidence interval (95{\%} CI), 1.32-1.57] and more likely to be inactive (OR, 1.74; 95{\%} CI, 1.56-1.94) in comparison with the BRFSS general population. Survivors treated with >20-Gy cranial radiotherapy were at particular risk. Compared with BRFSS participants and adjusted for age, race, and ethnicity, survivors were more likely to not meet CDC recommendations (females: OR, 2.07, 95{\%} CI, 1.67-2.56; males: OR, 1.43, 95{\%} CI, 1.16-1.76) and more likely to be inactive (females: OR, 1.86; 95{\%} CI, 1.50-2.31; males: OR, 1.84; 95{\%} CI, 1.45-2.32). Conclusions: Long-term survivors of childhood ALL are less likely to meet physical activity recommendations and more likely to report no leisure-time physical activity in the past month. This level of inactivity likely further increases their risk of cardiovascular disease, osteoporosis, and all-cause mortality.",
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T1 - Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia

T2 - A report from the childhood cancer survivor study

AU - Florin, Todd A.

AU - Fryer, G. Edgar

AU - Miyoshi, Thomas

AU - Weitzman, Michael

AU - Mertens, Ann C.

AU - Hudson, Melissa M.

AU - Sklar, Charles A.

AU - Emmons, Karen

AU - Hinkle, Andrea

AU - Whitton, John

AU - Stovall, Marilyn

AU - Robison, Leslie L.

AU - Oeffinger, Kevin C.

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N2 - Purpose: To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors. Patients and Methods: Physical activity was assessed by self-report in 2,648 adult survivors of the Childhood Cancer Survivor Study. Participants in the Behavioral Risk Factor Surveillance System (BRFSS) survey administered through the Centers for Disease Control and Prevention (CDC) were used as a comparison group. Results: Survivors had a mean age of 28.7 years (range, 18.0-44.0 years) and were a mean of 23.1 years from their cancer diagnosis (range, 16.0-33.8 years). In multivariate models, ALL survivors were more likely to not meet CDC recommendations for physical activity [odds ratio (OR), 1.44; 95% confidence interval (95% CI), 1.32-1.57] and more likely to be inactive (OR, 1.74; 95% CI, 1.56-1.94) in comparison with the BRFSS general population. Survivors treated with >20-Gy cranial radiotherapy were at particular risk. Compared with BRFSS participants and adjusted for age, race, and ethnicity, survivors were more likely to not meet CDC recommendations (females: OR, 2.07, 95% CI, 1.67-2.56; males: OR, 1.43, 95% CI, 1.16-1.76) and more likely to be inactive (females: OR, 1.86; 95% CI, 1.50-2.31; males: OR, 1.84; 95% CI, 1.45-2.32). Conclusions: Long-term survivors of childhood ALL are less likely to meet physical activity recommendations and more likely to report no leisure-time physical activity in the past month. This level of inactivity likely further increases their risk of cardiovascular disease, osteoporosis, and all-cause mortality.

AB - Purpose: To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors. Patients and Methods: Physical activity was assessed by self-report in 2,648 adult survivors of the Childhood Cancer Survivor Study. Participants in the Behavioral Risk Factor Surveillance System (BRFSS) survey administered through the Centers for Disease Control and Prevention (CDC) were used as a comparison group. Results: Survivors had a mean age of 28.7 years (range, 18.0-44.0 years) and were a mean of 23.1 years from their cancer diagnosis (range, 16.0-33.8 years). In multivariate models, ALL survivors were more likely to not meet CDC recommendations for physical activity [odds ratio (OR), 1.44; 95% confidence interval (95% CI), 1.32-1.57] and more likely to be inactive (OR, 1.74; 95% CI, 1.56-1.94) in comparison with the BRFSS general population. Survivors treated with >20-Gy cranial radiotherapy were at particular risk. Compared with BRFSS participants and adjusted for age, race, and ethnicity, survivors were more likely to not meet CDC recommendations (females: OR, 2.07, 95% CI, 1.67-2.56; males: OR, 1.43, 95% CI, 1.16-1.76) and more likely to be inactive (females: OR, 1.86; 95% CI, 1.50-2.31; males: OR, 1.84; 95% CI, 1.45-2.32). Conclusions: Long-term survivors of childhood ALL are less likely to meet physical activity recommendations and more likely to report no leisure-time physical activity in the past month. This level of inactivity likely further increases their risk of cardiovascular disease, osteoporosis, and all-cause mortality.

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