Phylogenetic relationships of hominids: Biomolecular approach

Todd Disotell

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Biomolecules, in particular DNA, assist us in generating and testing hypotheses about human evolutionary history. Molecular analyses testing for and then utilizing a local molecular clock can inform us as to the timing of the split between different lineages or populations. When applied to the split between hominins and chimpanzees, for instance, the molecular clock estimates of their divergence date place constraints on interpretations of the growing fossil record from the Late Miocene and Early Pliocene. The pattern and distribution of modern human variation can be used to extrapolate back in time to infer when and where the modern human gene pool arose. Mitochondrial DNA and Y chromosome sequences and markers have been extensively surveyed in populations from around the world. Numerous nuclear loci and other markers, such as microsatellites and Alu insertions, have similarly been sampled and analyzed. More recently, high-throughput massively parallel sequencing technologies have allowed for the characterization of hundreds of human and nonhuman primate complete genomes. The majority of such analyses point toward a relatively recent origin for modern human diversity from a small population in Africa within the last 200 Ka, with a subsequent dispersal into Eurasia less than 100 Ka though there is some debate as to the timing of these events. While analyses of ancient mitochondrial sequences from archaic hominins strongly suggest that archaic females did not contribute to the modern human mitochondrial gene pool, whole-genome sequences of two archaic populations suggest limited interbreeding with modern humans in Eurasia but not Africa. Analyses of modern African genomes suggest that some populations also interbred with an as yet unknown archaic population or populations. Thus, while a complete replacement of archaic populations by African-derived modern humans is no longer fully tenable, only a limited amount interbreeding between anatomically modern human populations and archaic forebears is likely to have taken place.

    Original languageEnglish (US)
    Title of host publicationHandbook of Paleoanthropology, Second Edition
    PublisherSpringer Berlin Heidelberg
    Pages2015-2041
    Number of pages27
    ISBN (Electronic)9783642399794
    ISBN (Print)9783642399787
    DOIs
    StatePublished - Jan 1 2015

    Fingerprint

    hominid
    Hominidae
    genome
    phylogenetics
    phylogeny
    Population
    gene
    hypothesis testing
    fossil record
    primate
    mitochondrial DNA
    Gene Pool
    chromosome
    Eurasia
    Pliocene
    replacement
    divergence
    Miocene
    Genome
    DNA

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Earth and Planetary Sciences(all)
    • Social Sciences(all)

    Cite this

    Disotell, T. (2015). Phylogenetic relationships of hominids: Biomolecular approach. In Handbook of Paleoanthropology, Second Edition (pp. 2015-2041). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-39979-4_59

    Phylogenetic relationships of hominids : Biomolecular approach. / Disotell, Todd.

    Handbook of Paleoanthropology, Second Edition. Springer Berlin Heidelberg, 2015. p. 2015-2041.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Disotell, T 2015, Phylogenetic relationships of hominids: Biomolecular approach. in Handbook of Paleoanthropology, Second Edition. Springer Berlin Heidelberg, pp. 2015-2041. https://doi.org/10.1007/978-3-642-39979-4_59
    Disotell T. Phylogenetic relationships of hominids: Biomolecular approach. In Handbook of Paleoanthropology, Second Edition. Springer Berlin Heidelberg. 2015. p. 2015-2041 https://doi.org/10.1007/978-3-642-39979-4_59
    Disotell, Todd. / Phylogenetic relationships of hominids : Biomolecular approach. Handbook of Paleoanthropology, Second Edition. Springer Berlin Heidelberg, 2015. pp. 2015-2041
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