Photochemical Tools for Remote Control of Ion Channels in Excitable Cells

Richard H. Kramer, James J. Chambers, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Various strategies have been developed recently for imparting light sensitivity onto normally insensitive cells. These include expression of natural photosensitive proteins, photolysis of caged agonists of native cell surface receptors and photoswitching of isomerizable tethered ligands that act on specially engineered ion channels and receptor targets. The development of chemical tools for optically stimulating or inhibiting signaling proteins has particular relevance for the nervous system, where precise, noninvasive control is an experimental and medical necessity.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalNature Chemical Biology
Volume1
Issue number7
DOIs
StatePublished - 2005

Fingerprint

Ion Channels
Photophobia
Photolysis
Cell Surface Receptors
Nervous System
Proteins
Ligands

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Photochemical Tools for Remote Control of Ion Channels in Excitable Cells. / Kramer, Richard H.; Chambers, James J.; Trauner, Dirk.

In: Nature Chemical Biology, Vol. 1, No. 7, 2005, p. 360-365.

Research output: Contribution to journalArticle

Kramer, Richard H. ; Chambers, James J. ; Trauner, Dirk. / Photochemical Tools for Remote Control of Ion Channels in Excitable Cells. In: Nature Chemical Biology. 2005 ; Vol. 1, No. 7. pp. 360-365.
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