Phencyclidine discoordinates hippocampal network activity but not place fields

Hsin Yi Kao, Dino Dvořák, Eunhye Park, Jana Kenney, Eduard Kelemen, Andre Fenton

Research output: Contribution to journalArticle

Abstract

We used the psychotomimetic phencyclidine (PCP) to investigate the relationships among cognitive behavior, coordinated neural network function, and information processing within the hippocampus place cell system. We report in rats that PCP (5 mg/kg, i.p.) impairs a well learned, hippocampus-dependent place avoidance behavior in rats that requires cognitive control even when PCP is injected directly into dorsal hippocampus. PCP increases 60–100 Hz medium-freguency gamma oscillations in hippocampus CA1 and these increases correlate with the cognitive impairment caused by systemic PCP administration. PCP discoordinates theta-modulated medium-frequency and slow gamma oscillations in CA1 LFPs such that medium-frequency gamma oscillations become more theta-organized than slow gamma oscillations. CA1 place cell firing fields are preserved under PCP, but the drug discoordinates the subsecond temporal organization of discharge among place cells. This discoordination causes place cell ensemble representations of a familiar space to cease resembling pre-PCP representations despite preserved place fields. These findings point to the cognitive impairments caused by PCP arising from neural discoordination. PCP disrupts the timing of discharge with respect to the subsecond timescales of theta and gamma oscillations in the LFP. Because these oscillations arise from local inhibitory synaptic activity, these findings point to excitation– inhibition discoordination as the root of PCP-induced cognitive impairment.

Original languageEnglish (US)
Pages (from-to)12031-12049
Number of pages19
JournalJournal of Neuroscience
Volume37
Issue number49
DOIs
StatePublished - Dec 6 2017

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Phencyclidine
Hippocampus
Avoidance Learning
Automatic Data Processing

Keywords

  • Gamma
  • Neural discoordination
  • NMDA antagonist
  • Oscillations
  • Place cell
  • Theta

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Phencyclidine discoordinates hippocampal network activity but not place fields. / Kao, Hsin Yi; Dvořák, Dino; Park, Eunhye; Kenney, Jana; Kelemen, Eduard; Fenton, Andre.

In: Journal of Neuroscience, Vol. 37, No. 49, 06.12.2017, p. 12031-12049.

Research output: Contribution to journalArticle

Kao, Hsin Yi ; Dvořák, Dino ; Park, Eunhye ; Kenney, Jana ; Kelemen, Eduard ; Fenton, Andre. / Phencyclidine discoordinates hippocampal network activity but not place fields. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 49. pp. 12031-12049.
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