Perspectives on the mitochondrial multiple conductance channel

Kathleen W. Kinnally, Timothy A. Lohret, Maria Luisa Campo, Carmen A. Mannella

Research output: Contribution to journalArticle

Abstract

A multiple conductance channel (MCC) with a peak conductance of over 1 nS is recorded from mitoplasts (mitochondria with the inner membrane exposed) using patch-clamp techniques. MCC shares many general characteristics with other intracellular megachannels, many of which are weakly selective, voltage-dependent, and calcium sensitive. A role in protein import is suggested by the transient blockade of MCC by peptides responsible for targeting mitochondrial precursor proteins. MCC is compared with the peptide- sensitive channel of the outer membrane because of similarities in targeting peptide blockade. The pharmacology and regulation of MCC by physiological effectors are reviewed and compared with the properties of the pore hypothesized to be responsible for the mitochondrial inner membrane permeability transition.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalJournal of Bioenergetics and Biomembranes
Volume28
Issue number2
DOIs
StatePublished - 1996

Fingerprint

Peptides
Membranes
Mitochondrial Proteins
Mitochondrial Membranes
Patch-Clamp Techniques
Permeability
Mitochondria
Pharmacology
Calcium
Proteins
peptide sensitive channel

Keywords

  • intracellular channel
  • Mitochondria
  • mitochondrial megachannel
  • multiple conductance channel
  • patch clamp
  • peptide-sensitive channel
  • permeability transition
  • protein import

ASJC Scopus subject areas

  • Cell Biology
  • Physiology

Cite this

Kinnally, K. W., Lohret, T. A., Campo, M. L., & Mannella, C. A. (1996). Perspectives on the mitochondrial multiple conductance channel. Journal of Bioenergetics and Biomembranes, 28(2), 115-123. https://doi.org/10.1007/BF02110641

Perspectives on the mitochondrial multiple conductance channel. / Kinnally, Kathleen W.; Lohret, Timothy A.; Campo, Maria Luisa; Mannella, Carmen A.

In: Journal of Bioenergetics and Biomembranes, Vol. 28, No. 2, 1996, p. 115-123.

Research output: Contribution to journalArticle

Kinnally, KW, Lohret, TA, Campo, ML & Mannella, CA 1996, 'Perspectives on the mitochondrial multiple conductance channel', Journal of Bioenergetics and Biomembranes, vol. 28, no. 2, pp. 115-123. https://doi.org/10.1007/BF02110641
Kinnally, Kathleen W. ; Lohret, Timothy A. ; Campo, Maria Luisa ; Mannella, Carmen A. / Perspectives on the mitochondrial multiple conductance channel. In: Journal of Bioenergetics and Biomembranes. 1996 ; Vol. 28, No. 2. pp. 115-123.
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