PERspective on PER phosphorylation

Research output: Contribution to journalArticle

Abstract

Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER's stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (pp. 1758-1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

Original languageEnglish (US)
Pages (from-to)1737-1740
Number of pages4
JournalGenes & development
Volume22
Issue number13
DOIs
StatePublished - Jul 1 2008

Fingerprint

Period Circadian Proteins
Phosphorylation
F-Box Proteins
Circadian Rhythm
Diptera
Mammals
Phosphotransferases
Genes

Keywords

  • β-TrCP/SLIMB
  • Circadian rhythms
  • CK1ε/DBT
  • Drosophila
  • F-box protein
  • PER
  • Phosphorylation

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics

Cite this

PERspective on PER phosphorylation. / Blau, Justin.

In: Genes & development, Vol. 22, No. 13, 01.07.2008, p. 1737-1740.

Research output: Contribution to journalArticle

Blau, Justin. / PERspective on PER phosphorylation. In: Genes & development. 2008 ; Vol. 22, No. 13. pp. 1737-1740.
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