Personality polygenes, positive affect, and life satisfaction

Alexander Weiss, Bart M L Baselmans, Edith Hofer, Jingyun Yang, Aysu Okbay, Penelope A. Lind, Mike B. Miller, Ilja M. Nolte, Wei Zhao, Saskia P. Hagenaars, Jouke Jan Hottenga, Lindsay K. Matteson, Harold Snieder, Jessica D. Faul, Catharina A. Hartman, Patricia A. Boyle, Henning Tiemeier, Miriam A. Mosing, Alison Pattie, Gail DaviesDavid C. Liewald, Reinhold Schmidt, Philip L. De Jager, Andrew C. Heath, Markus Jokela, John M. Starr, Albertine J. Oldehinkel, Magnus Johannesson, David Cesarini, Albert Hofman, Sarah E. Harris, Jennifer A. Smith, Liisa Keltikangas-Järvinen, Laura Pulkki-Råback, Helena Schmidt, Jacqui Smith, William G. Iacono, Matt McGue, David A. Bennett, Nancy L. Pedersen, Patrik K E Magnusson, Ian J. Deary, Nicholas G. Martin, Dorret I. Boomsma, Meike Bartels, Michelle Luciano

    Research output: Contribution to journalArticle

    Abstract

    Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.

    Original languageEnglish (US)
    Pages (from-to)407-417
    Number of pages11
    JournalTwin Research and Human Genetics
    Volume19
    Issue number5
    DOIs
    StatePublished - Oct 1 2016

    Fingerprint

    Personality
    Equipment and Supplies
    Genome
    Personality Inventory
    Genetic Research
    Pedigree
    Primates
    Meta-Analysis
    Neuroticism
    Extraversion (Psychology)

    Keywords

    • genetic correlation
    • genetics
    • happiness
    • polygenic prediction
    • wellbeing

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology
    • Genetics(clinical)

    Cite this

    Weiss, A., Baselmans, B. M. L., Hofer, E., Yang, J., Okbay, A., Lind, P. A., ... Luciano, M. (2016). Personality polygenes, positive affect, and life satisfaction. Twin Research and Human Genetics, 19(5), 407-417. https://doi.org/10.1017/thg.2016.65

    Personality polygenes, positive affect, and life satisfaction. / Weiss, Alexander; Baselmans, Bart M L; Hofer, Edith; Yang, Jingyun; Okbay, Aysu; Lind, Penelope A.; Miller, Mike B.; Nolte, Ilja M.; Zhao, Wei; Hagenaars, Saskia P.; Hottenga, Jouke Jan; Matteson, Lindsay K.; Snieder, Harold; Faul, Jessica D.; Hartman, Catharina A.; Boyle, Patricia A.; Tiemeier, Henning; Mosing, Miriam A.; Pattie, Alison; Davies, Gail; Liewald, David C.; Schmidt, Reinhold; De Jager, Philip L.; Heath, Andrew C.; Jokela, Markus; Starr, John M.; Oldehinkel, Albertine J.; Johannesson, Magnus; Cesarini, David; Hofman, Albert; Harris, Sarah E.; Smith, Jennifer A.; Keltikangas-Järvinen, Liisa; Pulkki-Råback, Laura; Schmidt, Helena; Smith, Jacqui; Iacono, William G.; McGue, Matt; Bennett, David A.; Pedersen, Nancy L.; Magnusson, Patrik K E; Deary, Ian J.; Martin, Nicholas G.; Boomsma, Dorret I.; Bartels, Meike; Luciano, Michelle.

    In: Twin Research and Human Genetics, Vol. 19, No. 5, 01.10.2016, p. 407-417.

    Research output: Contribution to journalArticle

    Weiss, A, Baselmans, BML, Hofer, E, Yang, J, Okbay, A, Lind, PA, Miller, MB, Nolte, IM, Zhao, W, Hagenaars, SP, Hottenga, JJ, Matteson, LK, Snieder, H, Faul, JD, Hartman, CA, Boyle, PA, Tiemeier, H, Mosing, MA, Pattie, A, Davies, G, Liewald, DC, Schmidt, R, De Jager, PL, Heath, AC, Jokela, M, Starr, JM, Oldehinkel, AJ, Johannesson, M, Cesarini, D, Hofman, A, Harris, SE, Smith, JA, Keltikangas-Järvinen, L, Pulkki-Råback, L, Schmidt, H, Smith, J, Iacono, WG, McGue, M, Bennett, DA, Pedersen, NL, Magnusson, PKE, Deary, IJ, Martin, NG, Boomsma, DI, Bartels, M & Luciano, M 2016, 'Personality polygenes, positive affect, and life satisfaction', Twin Research and Human Genetics, vol. 19, no. 5, pp. 407-417. https://doi.org/10.1017/thg.2016.65
    Weiss A, Baselmans BML, Hofer E, Yang J, Okbay A, Lind PA et al. Personality polygenes, positive affect, and life satisfaction. Twin Research and Human Genetics. 2016 Oct 1;19(5):407-417. https://doi.org/10.1017/thg.2016.65
    Weiss, Alexander ; Baselmans, Bart M L ; Hofer, Edith ; Yang, Jingyun ; Okbay, Aysu ; Lind, Penelope A. ; Miller, Mike B. ; Nolte, Ilja M. ; Zhao, Wei ; Hagenaars, Saskia P. ; Hottenga, Jouke Jan ; Matteson, Lindsay K. ; Snieder, Harold ; Faul, Jessica D. ; Hartman, Catharina A. ; Boyle, Patricia A. ; Tiemeier, Henning ; Mosing, Miriam A. ; Pattie, Alison ; Davies, Gail ; Liewald, David C. ; Schmidt, Reinhold ; De Jager, Philip L. ; Heath, Andrew C. ; Jokela, Markus ; Starr, John M. ; Oldehinkel, Albertine J. ; Johannesson, Magnus ; Cesarini, David ; Hofman, Albert ; Harris, Sarah E. ; Smith, Jennifer A. ; Keltikangas-Järvinen, Liisa ; Pulkki-Råback, Laura ; Schmidt, Helena ; Smith, Jacqui ; Iacono, William G. ; McGue, Matt ; Bennett, David A. ; Pedersen, Nancy L. ; Magnusson, Patrik K E ; Deary, Ian J. ; Martin, Nicholas G. ; Boomsma, Dorret I. ; Bartels, Meike ; Luciano, Michelle. / Personality polygenes, positive affect, and life satisfaction. In: Twin Research and Human Genetics. 2016 ; Vol. 19, No. 5. pp. 407-417.
    @article{aa650e76296547dcb480f4d8423828b0,
    title = "Personality polygenes, positive affect, and life satisfaction",
    abstract = "Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05{\%}) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.",
    keywords = "genetic correlation, genetics, happiness, polygenic prediction, wellbeing",
    author = "Alexander Weiss and Baselmans, {Bart M L} and Edith Hofer and Jingyun Yang and Aysu Okbay and Lind, {Penelope A.} and Miller, {Mike B.} and Nolte, {Ilja M.} and Wei Zhao and Hagenaars, {Saskia P.} and Hottenga, {Jouke Jan} and Matteson, {Lindsay K.} and Harold Snieder and Faul, {Jessica D.} and Hartman, {Catharina A.} and Boyle, {Patricia A.} and Henning Tiemeier and Mosing, {Miriam A.} and Alison Pattie and Gail Davies and Liewald, {David C.} and Reinhold Schmidt and {De Jager}, {Philip L.} and Heath, {Andrew C.} and Markus Jokela and Starr, {John M.} and Oldehinkel, {Albertine J.} and Magnus Johannesson and David Cesarini and Albert Hofman and Harris, {Sarah E.} and Smith, {Jennifer A.} and Liisa Keltikangas-J{\~A}¤rvinen and Laura Pulkki-R{\~A}¥back and Helena Schmidt and Jacqui Smith and Iacono, {William G.} and Matt McGue and Bennett, {David A.} and Pedersen, {Nancy L.} and Magnusson, {Patrik K E} and Deary, {Ian J.} and Martin, {Nicholas G.} and Boomsma, {Dorret I.} and Meike Bartels and Michelle Luciano",
    year = "2016",
    month = "10",
    day = "1",
    doi = "10.1017/thg.2016.65",
    language = "English (US)",
    volume = "19",
    pages = "407--417",
    journal = "Twin Research and Human Genetics",
    issn = "1832-4274",
    publisher = "Australian Academic Press",
    number = "5",

    }

    TY - JOUR

    T1 - Personality polygenes, positive affect, and life satisfaction

    AU - Weiss, Alexander

    AU - Baselmans, Bart M L

    AU - Hofer, Edith

    AU - Yang, Jingyun

    AU - Okbay, Aysu

    AU - Lind, Penelope A.

    AU - Miller, Mike B.

    AU - Nolte, Ilja M.

    AU - Zhao, Wei

    AU - Hagenaars, Saskia P.

    AU - Hottenga, Jouke Jan

    AU - Matteson, Lindsay K.

    AU - Snieder, Harold

    AU - Faul, Jessica D.

    AU - Hartman, Catharina A.

    AU - Boyle, Patricia A.

    AU - Tiemeier, Henning

    AU - Mosing, Miriam A.

    AU - Pattie, Alison

    AU - Davies, Gail

    AU - Liewald, David C.

    AU - Schmidt, Reinhold

    AU - De Jager, Philip L.

    AU - Heath, Andrew C.

    AU - Jokela, Markus

    AU - Starr, John M.

    AU - Oldehinkel, Albertine J.

    AU - Johannesson, Magnus

    AU - Cesarini, David

    AU - Hofman, Albert

    AU - Harris, Sarah E.

    AU - Smith, Jennifer A.

    AU - Keltikangas-Järvinen, Liisa

    AU - Pulkki-RÃ¥back, Laura

    AU - Schmidt, Helena

    AU - Smith, Jacqui

    AU - Iacono, William G.

    AU - McGue, Matt

    AU - Bennett, David A.

    AU - Pedersen, Nancy L.

    AU - Magnusson, Patrik K E

    AU - Deary, Ian J.

    AU - Martin, Nicholas G.

    AU - Boomsma, Dorret I.

    AU - Bartels, Meike

    AU - Luciano, Michelle

    PY - 2016/10/1

    Y1 - 2016/10/1

    N2 - Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.

    AB - Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.

    KW - genetic correlation

    KW - genetics

    KW - happiness

    KW - polygenic prediction

    KW - wellbeing

    UR - http://www.scopus.com/inward/record.url?scp=84983036849&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84983036849&partnerID=8YFLogxK

    U2 - 10.1017/thg.2016.65

    DO - 10.1017/thg.2016.65

    M3 - Article

    VL - 19

    SP - 407

    EP - 417

    JO - Twin Research and Human Genetics

    JF - Twin Research and Human Genetics

    SN - 1832-4274

    IS - 5

    ER -