Persistent modifications of hippocampal synaptic function during remote spatial memory

Alice Pavlowsky, Emma Wallace, Andre Fenton, Juan Marcos Alarcon

Research output: Contribution to journalArticle

Abstract

A widely accepted notion for a process underlying memory formation is that learning changes the efficacy of synapses by the mechanism of synaptic plasticity. While there is compelling evidence of changes in synaptic efficacy observed after learning, demonstration of persistent synaptic changes accompanying memory has been elusive. We report that acquisition of a hippocampus and long-term potentiation dependent place memory persistently changes the function of CA1 synapses. Using extracellular recordings we measured CA3-CA1 and EC-CA1 synaptic responses and found robust changes in the CA3-CA1 pathway after memory training. Crucially, these changes in synaptic function lasted at least a month and coincided with the persistence of long-term place memories; the changes were only observed in animals that expressed robust memory, and not in animals with poor memory recall. Interestingly, our findings were observed at the level of populations of synapses; suggesting that memory formation recruits widespread synaptic circuits and persistently reorganizes their function to store information.

Original languageEnglish (US)
JournalNeurobiology of Learning and Memory
DOIs
StateAccepted/In press - Apr 6 2016

Fingerprint

Long-Term Memory
Synapses
Learning
Neuronal Plasticity
Long-Term Potentiation
Spatial Memory
Hippocampus
Population

Keywords

  • Active place avoidance
  • CA1
  • Hippocampus
  • Memory
  • Remote memory
  • Schema
  • Synaptic circuits
  • Synaptic plasticity

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Persistent modifications of hippocampal synaptic function during remote spatial memory. / Pavlowsky, Alice; Wallace, Emma; Fenton, Andre; Alarcon, Juan Marcos.

In: Neurobiology of Learning and Memory, 06.04.2016.

Research output: Contribution to journalArticle

@article{9e718430a25b4ac0a7cd067c286385a6,
title = "Persistent modifications of hippocampal synaptic function during remote spatial memory",
abstract = "A widely accepted notion for a process underlying memory formation is that learning changes the efficacy of synapses by the mechanism of synaptic plasticity. While there is compelling evidence of changes in synaptic efficacy observed after learning, demonstration of persistent synaptic changes accompanying memory has been elusive. We report that acquisition of a hippocampus and long-term potentiation dependent place memory persistently changes the function of CA1 synapses. Using extracellular recordings we measured CA3-CA1 and EC-CA1 synaptic responses and found robust changes in the CA3-CA1 pathway after memory training. Crucially, these changes in synaptic function lasted at least a month and coincided with the persistence of long-term place memories; the changes were only observed in animals that expressed robust memory, and not in animals with poor memory recall. Interestingly, our findings were observed at the level of populations of synapses; suggesting that memory formation recruits widespread synaptic circuits and persistently reorganizes their function to store information.",
keywords = "Active place avoidance, CA1, Hippocampus, Memory, Remote memory, Schema, Synaptic circuits, Synaptic plasticity",
author = "Alice Pavlowsky and Emma Wallace and Andre Fenton and Alarcon, {Juan Marcos}",
year = "2016",
month = "4",
day = "6",
doi = "10.1016/j.nlm.2016.08.015",
language = "English (US)",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Persistent modifications of hippocampal synaptic function during remote spatial memory

AU - Pavlowsky, Alice

AU - Wallace, Emma

AU - Fenton, Andre

AU - Alarcon, Juan Marcos

PY - 2016/4/6

Y1 - 2016/4/6

N2 - A widely accepted notion for a process underlying memory formation is that learning changes the efficacy of synapses by the mechanism of synaptic plasticity. While there is compelling evidence of changes in synaptic efficacy observed after learning, demonstration of persistent synaptic changes accompanying memory has been elusive. We report that acquisition of a hippocampus and long-term potentiation dependent place memory persistently changes the function of CA1 synapses. Using extracellular recordings we measured CA3-CA1 and EC-CA1 synaptic responses and found robust changes in the CA3-CA1 pathway after memory training. Crucially, these changes in synaptic function lasted at least a month and coincided with the persistence of long-term place memories; the changes were only observed in animals that expressed robust memory, and not in animals with poor memory recall. Interestingly, our findings were observed at the level of populations of synapses; suggesting that memory formation recruits widespread synaptic circuits and persistently reorganizes their function to store information.

AB - A widely accepted notion for a process underlying memory formation is that learning changes the efficacy of synapses by the mechanism of synaptic plasticity. While there is compelling evidence of changes in synaptic efficacy observed after learning, demonstration of persistent synaptic changes accompanying memory has been elusive. We report that acquisition of a hippocampus and long-term potentiation dependent place memory persistently changes the function of CA1 synapses. Using extracellular recordings we measured CA3-CA1 and EC-CA1 synaptic responses and found robust changes in the CA3-CA1 pathway after memory training. Crucially, these changes in synaptic function lasted at least a month and coincided with the persistence of long-term place memories; the changes were only observed in animals that expressed robust memory, and not in animals with poor memory recall. Interestingly, our findings were observed at the level of populations of synapses; suggesting that memory formation recruits widespread synaptic circuits and persistently reorganizes their function to store information.

KW - Active place avoidance

KW - CA1

KW - Hippocampus

KW - Memory

KW - Remote memory

KW - Schema

KW - Synaptic circuits

KW - Synaptic plasticity

UR - http://www.scopus.com/inward/record.url?scp=84995519536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995519536&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2016.08.015

DO - 10.1016/j.nlm.2016.08.015

M3 - Article

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

ER -