Permeability study of vertebral cancellous bone using micro-computational fluid dynamics

Jeremy Teo, Swee Hin Teoh

    Research output: Contribution to journalArticle

    Abstract

    Understanding of cancellous bone permeability is lacking despite its importance in designing tissue engineering scaffolds for bone regeneration and orthopaedic surgery that relies on infiltration of bone cement into porous cancellous bone. We employed micro-computational fluid dynamics to investigate permeability for 37 cancellous bone specimens, eliminating stringent technical requirements of bench-top testing. Microarchitectural parameters were also determined for the specimens and correlated, using uni-variate and multi-variate regression analyses, against permeability. We determined that bone surface density, trabecular pattern factor, structure model index and trabecular number are other possible predictors of permeability (with R values of 0.47, 0.44, 0.40 and 0.33), in addition to the commonly used porosity parameter (R value of 0.38). Pooling these parameters and performing multi-variate linear regression analysis improved yield the R-value of 0.50, indicating that porosity alone is a poor predictor of cancellous bone permeability and, therefore, other parameters should be included for a better and improved linear model.

    Original languageEnglish (US)
    Pages (from-to)417-423
    Number of pages7
    JournalComputer Methods in Biomechanics and Biomedical Engineering
    Volume15
    Issue number4
    DOIs
    StatePublished - Apr 1 2012

    Fingerprint

    Bone
    Computational fluid dynamics
    Porosity
    Tissue Scaffolds
    Bone cement
    Bone Cements
    Orthopedics
    Scaffolds (biology)
    Model structures
    Tissue engineering
    Infiltration
    Linear regression
    Regression analysis
    Surgery
    Testing

    Keywords

    • Bone biomechanics
    • Micro-computational fluid dynamics
    • Permeability

    ASJC Scopus subject areas

    • Bioengineering
    • Biomedical Engineering
    • Human-Computer Interaction
    • Computer Science Applications

    Cite this

    Permeability study of vertebral cancellous bone using micro-computational fluid dynamics. / Teo, Jeremy; Teoh, Swee Hin.

    In: Computer Methods in Biomechanics and Biomedical Engineering, Vol. 15, No. 4, 01.04.2012, p. 417-423.

    Research output: Contribution to journalArticle

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