Periodontal pathogens and gestational diabetes mellitus

Ananda Dasanayake, N. Chhun, A. C R Tanner, Ronald Craig, M. J. Lee, A. F. Moore, R. G. Norman

Research output: Contribution to journalArticle

Abstract

In previous cross-sectional or case-control studies, clinical periodontal disease has been associated with gestational diabetes mellitus. To test the hypothesis that, in comparison with women who do not develop gestational diabetes mellitus, those who do develop it will have had a greater exposure to clinical and other periodontal parameters, we measured clinical, bacteriological (in plaque and cervico-vaginal samples), immunological, and inflammatory mediator parameters 7 weeks before the diagnosis of gestational diabetes mellitus in 265 predominantly Hispanic (83%) women in New York. Twenty-two cases of gestational diabetes mellitus emerged from the cohort (8.3%). When the cases were compared with healthy control individuals, higher pre-pregnancy body mass index (p = 0.004), vaginal levels of Tannerella forsythia (p = 0.01), serum C-reactive protein (p = 0.01), and prior gestational diabetes mellitus (p = 0.006) emerged as risk factors, even though the clinical periodontal disease failed to reach statistical significance (50% in those with gestational diabetes mellitus vs. 37.3% in the healthy group; p = 0.38).

Original languageEnglish (US)
Pages (from-to)328-333
Number of pages6
JournalJournal of Dental Research
Volume87
Issue number4
DOIs
StatePublished - Apr 2008

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Gestational Diabetes
Periodontal Diseases
Hispanic Americans
C-Reactive Protein
Case-Control Studies
Blood Proteins
Body Mass Index
Pregnancy

Keywords

  • Gestational diabetes mellitus
  • Maternal periodontal disease
  • Tannerella forsythia

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Dasanayake, A., Chhun, N., Tanner, A. C. R., Craig, R., Lee, M. J., Moore, A. F., & Norman, R. G. (2008). Periodontal pathogens and gestational diabetes mellitus. Journal of Dental Research, 87(4), 328-333. https://doi.org/10.1177/154405910808700421

Periodontal pathogens and gestational diabetes mellitus. / Dasanayake, Ananda; Chhun, N.; Tanner, A. C R; Craig, Ronald; Lee, M. J.; Moore, A. F.; Norman, R. G.

In: Journal of Dental Research, Vol. 87, No. 4, 04.2008, p. 328-333.

Research output: Contribution to journalArticle

Dasanayake, A, Chhun, N, Tanner, ACR, Craig, R, Lee, MJ, Moore, AF & Norman, RG 2008, 'Periodontal pathogens and gestational diabetes mellitus', Journal of Dental Research, vol. 87, no. 4, pp. 328-333. https://doi.org/10.1177/154405910808700421
Dasanayake, Ananda ; Chhun, N. ; Tanner, A. C R ; Craig, Ronald ; Lee, M. J. ; Moore, A. F. ; Norman, R. G. / Periodontal pathogens and gestational diabetes mellitus. In: Journal of Dental Research. 2008 ; Vol. 87, No. 4. pp. 328-333.
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