Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome

Angela Kamer, Juan O. Fortea, Sebastià Videla, Angela Mayoral, Malvin Janal, Maria Carmona-Iragui, Bessy Benejam, Ronald Craig, Deepak Saxena, Patricia Corby, Lidia Glodzik, Kumar Raghava Chowdary Annam, Miriam Robbins, Mony J. de Leon

Research output: Contribution to journalArticle

Abstract

People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume2
DOIs
StatePublished - 2016

Fingerprint

Periodontal Diseases
Down Syndrome
Disease Progression
Alzheimer Disease
Periodontitis
Aggressive Periodontitis
Inflammation
Age of Onset
Dementia
Infection
Population

Keywords

  • Aggressive periodontal disease
  • Alzheimer's disease
  • Down syndrome
  • Dysbiosis
  • Infection
  • Inflammation
  • Neuroinflammation
  • Periodontal disease
  • Trisomy 21

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. / Kamer, Angela; Fortea, Juan O.; Videla, Sebastià; Mayoral, Angela; Janal, Malvin; Carmona-Iragui, Maria; Benejam, Bessy; Craig, Ronald; Saxena, Deepak; Corby, Patricia; Glodzik, Lidia; Annam, Kumar Raghava Chowdary; Robbins, Miriam; de Leon, Mony J.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 2, 2016, p. 49-57.

Research output: Contribution to journalArticle

Kamer, A, Fortea, JO, Videla, S, Mayoral, A, Janal, M, Carmona-Iragui, M, Benejam, B, Craig, R, Saxena, D, Corby, P, Glodzik, L, Annam, KRC, Robbins, M & de Leon, MJ 2016, 'Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 2, pp. 49-57. https://doi.org/10.1016/j.dadm.2016.01.001
Kamer, Angela ; Fortea, Juan O. ; Videla, Sebastià ; Mayoral, Angela ; Janal, Malvin ; Carmona-Iragui, Maria ; Benejam, Bessy ; Craig, Ronald ; Saxena, Deepak ; Corby, Patricia ; Glodzik, Lidia ; Annam, Kumar Raghava Chowdary ; Robbins, Miriam ; de Leon, Mony J. / Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2016 ; Vol. 2. pp. 49-57.
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