Periodontal diseases and carotid intima-media thickness in Bangladesh

Fen Wu, Yu Chen, Ryan T. Demmer, Faruque Parvez, Rina Rani Paul, Ishrat Shaheen, Golam Sarwar, Alauddin Ahmed, Mahbub Eunus, Nafiz Ahsan, Nur Mohammad Habibullah, Tariqul Islam, Tatjana Rundek, Habibul Ahsan, Moise Desvarieux

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population. Methods: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT). Results: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01). Conclusions: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.

Original languageEnglish (US)
Pages (from-to)909-917
Number of pages9
JournalJournal of Clinical Periodontology
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Carotid Intima-Media Thickness
Bangladesh
Periodontal Diseases
Linear Models
Atherosclerosis
Matrix Metalloproteinase 9
Arsenic
Intercellular Adhesion Molecule-1
Population
Longitudinal Studies
Body Mass Index
Cross-Sectional Studies
Prospective Studies
Health

Keywords

  • atherosclerosis
  • Bangladesh
  • cardiovascular disease
  • carotid intima-media thickness
  • periodontal diseases

ASJC Scopus subject areas

  • Periodontics

Cite this

Wu, F., Chen, Y., Demmer, R. T., Parvez, F., Paul, R. R., Shaheen, I., ... Desvarieux, M. (2016). Periodontal diseases and carotid intima-media thickness in Bangladesh. Journal of Clinical Periodontology, 43(11), 909-917. https://doi.org/10.1111/jcpe.12597

Periodontal diseases and carotid intima-media thickness in Bangladesh. / Wu, Fen; Chen, Yu; Demmer, Ryan T.; Parvez, Faruque; Paul, Rina Rani; Shaheen, Ishrat; Sarwar, Golam; Ahmed, Alauddin; Eunus, Mahbub; Ahsan, Nafiz; Habibullah, Nur Mohammad; Islam, Tariqul; Rundek, Tatjana; Ahsan, Habibul; Desvarieux, Moise.

In: Journal of Clinical Periodontology, Vol. 43, No. 11, 01.11.2016, p. 909-917.

Research output: Contribution to journalArticle

Wu, F, Chen, Y, Demmer, RT, Parvez, F, Paul, RR, Shaheen, I, Sarwar, G, Ahmed, A, Eunus, M, Ahsan, N, Habibullah, NM, Islam, T, Rundek, T, Ahsan, H & Desvarieux, M 2016, 'Periodontal diseases and carotid intima-media thickness in Bangladesh', Journal of Clinical Periodontology, vol. 43, no. 11, pp. 909-917. https://doi.org/10.1111/jcpe.12597
Wu, Fen ; Chen, Yu ; Demmer, Ryan T. ; Parvez, Faruque ; Paul, Rina Rani ; Shaheen, Ishrat ; Sarwar, Golam ; Ahmed, Alauddin ; Eunus, Mahbub ; Ahsan, Nafiz ; Habibullah, Nur Mohammad ; Islam, Tariqul ; Rundek, Tatjana ; Ahsan, Habibul ; Desvarieux, Moise. / Periodontal diseases and carotid intima-media thickness in Bangladesh. In: Journal of Clinical Periodontology. 2016 ; Vol. 43, No. 11. pp. 909-917.
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AU - Chen, Yu

AU - Demmer, Ryan T.

AU - Parvez, Faruque

AU - Paul, Rina Rani

AU - Shaheen, Ishrat

AU - Sarwar, Golam

AU - Ahmed, Alauddin

AU - Eunus, Mahbub

AU - Ahsan, Nafiz

AU - Habibullah, Nur Mohammad

AU - Islam, Tariqul

AU - Rundek, Tatjana

AU - Ahsan, Habibul

AU - Desvarieux, Moise

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