Periodontal disease adversely affects the survival of patients with end-stage renal disease

Abhijit V. Kshirsagar, Ronald Craig, Kevin L. Moss, James D. Beck, Steven Offenbacher, Peter Kotanko, Philip J. Klemmer, Maki Yoshino, Nathan W. Levin, Julie Yip, Khalid Almas, Eva M. Lupovici, Len A. Usvyat, Ronald J. Falk

Research output: Contribution to journalArticle

Abstract

Periodontal disease is associated with cardiovascular disease and is thought to accelerate systemic atherosclerosis. Here we examined the relationship between periodontitis and cardiovascular disease mortality in outpatients on hemodialysis using a retrospective analysis of 168 adult patients in New York City and North Carolina. During 18 months of follow-up, cardiovascular disease and all-cause mortality were determined from a centralized dialysis registry. One hundred patients had mild or no periodontal disease but the remaining 68 had moderate-to-severe disease defined as 2 or more teeth with at least 6 mm of inter-proximal attachment loss. At baseline, the proportion of males was significantly lower in the moderate-to-severe group. Compared with mild or no periodontal disease, moderate-to-severe disease was significantly associated with death from cardiovascular causes. Adjustment for age, gender, center and dialysis vintage, smoking status, and history of diabetes mellitus or hypertension did not diminish the strength of this association. Our findings suggest a need for larger studies to confirm this connection, along with intervention trials to determine if treating periodontitis reduces cardiovascular disease mortality in dialysis patients.

Original languageEnglish (US)
Pages (from-to)746-751
Number of pages6
JournalKidney International
Volume75
Issue number7
DOIs
StatePublished - Apr 2009

Fingerprint

Periodontal Diseases
Chronic Kidney Failure
Cardiovascular Diseases
Dialysis
Survival
Periodontitis
Mortality
Registries
Renal Dialysis
Cause of Death
Atherosclerosis
Diabetes Mellitus
Tooth
Outpatients
Smoking
Hypertension

Keywords

  • CVD mortality
  • ESRD
  • Periodontitis

ASJC Scopus subject areas

  • Nephrology

Cite this

Kshirsagar, A. V., Craig, R., Moss, K. L., Beck, J. D., Offenbacher, S., Kotanko, P., ... Falk, R. J. (2009). Periodontal disease adversely affects the survival of patients with end-stage renal disease. Kidney International, 75(7), 746-751. https://doi.org/10.1038/ki.2008.660

Periodontal disease adversely affects the survival of patients with end-stage renal disease. / Kshirsagar, Abhijit V.; Craig, Ronald; Moss, Kevin L.; Beck, James D.; Offenbacher, Steven; Kotanko, Peter; Klemmer, Philip J.; Yoshino, Maki; Levin, Nathan W.; Yip, Julie; Almas, Khalid; Lupovici, Eva M.; Usvyat, Len A.; Falk, Ronald J.

In: Kidney International, Vol. 75, No. 7, 04.2009, p. 746-751.

Research output: Contribution to journalArticle

Kshirsagar, AV, Craig, R, Moss, KL, Beck, JD, Offenbacher, S, Kotanko, P, Klemmer, PJ, Yoshino, M, Levin, NW, Yip, J, Almas, K, Lupovici, EM, Usvyat, LA & Falk, RJ 2009, 'Periodontal disease adversely affects the survival of patients with end-stage renal disease', Kidney International, vol. 75, no. 7, pp. 746-751. https://doi.org/10.1038/ki.2008.660
Kshirsagar, Abhijit V. ; Craig, Ronald ; Moss, Kevin L. ; Beck, James D. ; Offenbacher, Steven ; Kotanko, Peter ; Klemmer, Philip J. ; Yoshino, Maki ; Levin, Nathan W. ; Yip, Julie ; Almas, Khalid ; Lupovici, Eva M. ; Usvyat, Len A. ; Falk, Ronald J. / Periodontal disease adversely affects the survival of patients with end-stage renal disease. In: Kidney International. 2009 ; Vol. 75, No. 7. pp. 746-751.
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