Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor

Stephen Arnold, Venkata Ramanaiah Dantham, Curtis Barbre, Bruce A. Garetz, Xudong Fan

Research output: Contribution to journalArticle

Abstract

We propose the attachment of a periodic array of gold nanoparticles (epitopes) to the equator of a Whispering Gallery Mode Biosensor for the purpose of plasmonically enhancing nanoparticle sensing in a self-referencing manner while increasing the capture rate of analyte to antibodies attached to these plasmonic epitopes. Our approach can be applied to a variety of whispering gallery mode resonators from silicon/silica rings and disks to capillaries. The interpretation of the signals is particularly simple since the optical phase difference between the epitopes is designed to be an integer multiple of π, allowing the wavelength shift from each binding event to add independently.

Original languageEnglish (US)
Pages (from-to)26147-26159
Number of pages13
JournalOptics Express
Volume20
Issue number24
StatePublished - Nov 19 2012

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whispering gallery modes
bioinstrumentation
nanoparticles
equators
antibodies
integers
attachment
resonators
gold
silicon dioxide
rings
shift
silicon
wavelengths

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor. / Arnold, Stephen; Dantham, Venkata Ramanaiah; Barbre, Curtis; Garetz, Bruce A.; Fan, Xudong.

In: Optics Express, Vol. 20, No. 24, 19.11.2012, p. 26147-26159.

Research output: Contribution to journalArticle

Arnold, S, Dantham, VR, Barbre, C, Garetz, BA & Fan, X 2012, 'Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor', Optics Express, vol. 20, no. 24, pp. 26147-26159.
Arnold, Stephen ; Dantham, Venkata Ramanaiah ; Barbre, Curtis ; Garetz, Bruce A. ; Fan, Xudong. / Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor. In: Optics Express. 2012 ; Vol. 20, No. 24. pp. 26147-26159.
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