Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor

Stephen Arnold, Venkata Ramanaiah Dantham, Curtis Barbre, Bruce A. Garetz, Xudong Fan

Research output: Contribution to journalArticle

Abstract

We propose the attachment of a periodic array of gold nanoparticles (epitopes) to the equator of a Whispering Gallery Mode Biosensor for the purpose of plasmonically enhancing nanoparticle sensing in a self-referencing manner while increasing the capture rate of analyte to antibodies attached to these plasmonic epitopes. Our approach can be applied to a variety of whispering gallery mode resonators from silicon/silica rings and disks to capillaries. The interpretation of the signals is particularly simple since the optical phase difference between the epitopes is designed to be an integer multiple of π, allowing the wavelength shift from each binding event to add independently.

Original languageEnglish (US)
Pages (from-to)26147-26159
Number of pages13
JournalOptics Express
Volume20
Issue number24
DOIs
StatePublished - Nov 19 2012

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ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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