Peptoid architectures: elaboration, actuation, and application

Barney Yoo, Kent Kirshenbaum

Research output: Contribution to journalReview article

Abstract

Peptoids are peptidomimetic oligomers composed of N-substituted glycine units. Their convenient synthesis enables strict control over the sequence of highly diverse monomers and is capable of generating extensive compound libraries. Recent studies are beginning to explore the relationship between peptoid sequence, structure and function. We describe new approaches to direct the conformation of the peptoid backbone, leading to secondary structures such as helices, loops, and turns. These advances are enabling the discovery of bioactive peptoids and will establish modules for the design and assembly of protein mimetics.

Original languageEnglish (US)
Pages (from-to)714-721
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume12
Issue number6
DOIs
StatePublished - Dec 1 2008

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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