Patterns of obesity and lymph fluid level during the first year of breast cancer treatment: A prospective study

Mei Fu, Deborah Axelrod, Amber A. Guth, Jason Fletcher, Jeanna M. Qiu, Joan Scagliola, Robin Kleinman, Caitlin E. Ryan, Nicholas Chan, Judith Haber

Research output: Contribution to journalArticle

Abstract

Obesity is one of the risk factors for developing lymphedema following breast cancer treatment. We prospectively enrolled 140 women and followed the participants for 12 months after surgery to investigate patterns of obesity and lymph fluid level in the first year of cancer treatment. Electrical bioimpedance devices were used to measure weight, BMI, and percent of body fat as well as lymph fluid level. General instructions were given to the participants on maintaining pre-surgery weight. Among the 140 participants, 136 completed the study with 2.9% attrition. More than 60% of the participants were obese (30.8%) or overweight (32.4%), while only two participants were underweight and about 35% had normal weight. This pattern of obesity and overweight was consistent at 4–8 weeks and 12 months post-surgery. At 12 months post-surgery, the majority of the women (72.1%) maintained pre-surgery weight and 15.4% had >5% weight loss; 12.5% of the women increase >5% of their weight. Significantly more patients in the obesity group had lymphedema defined by L-Dex ratio >7.1 than those in the normal/underweight and overweight group at pre-surgery and 4–8 weeks post-surgery. There was a trend of more patients in the obesity group had L-Dex ratio >7.1 at 12 months post-surgery. Obesity and overweight remain among women at the time of cancer diagnosis and the patterns of obesity and overweight continue during the first year of treatment. General instructions on having nutrition-balanced and portion-appropriate diet and physical activities daily or weekly can be effective to maintain pre-surgery weight.

Original languageEnglish (US)
Pages (from-to)326-340
Number of pages15
JournalJournal of Personalized Medicine
Volume5
Issue number3
DOIs
StatePublished - Sep 3 2015

Fingerprint

Lymph
Obesity
Prospective Studies
Breast Neoplasms
Weights and Measures
Therapeutics
Thinness
Lymphedema
Adipose Tissue
Weight Loss
Neoplasms
Exercise
Diet
Equipment and Supplies

Keywords

  • Body mass index
  • Breast cancer
  • Lymph fluid
  • Lymphedema
  • Obesity
  • Overweight

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Patterns of obesity and lymph fluid level during the first year of breast cancer treatment : A prospective study. / Fu, Mei; Axelrod, Deborah; Guth, Amber A.; Fletcher, Jason; Qiu, Jeanna M.; Scagliola, Joan; Kleinman, Robin; Ryan, Caitlin E.; Chan, Nicholas; Haber, Judith.

In: Journal of Personalized Medicine, Vol. 5, No. 3, 03.09.2015, p. 326-340.

Research output: Contribution to journalArticle

Fu, M, Axelrod, D, Guth, AA, Fletcher, J, Qiu, JM, Scagliola, J, Kleinman, R, Ryan, CE, Chan, N & Haber, J 2015, 'Patterns of obesity and lymph fluid level during the first year of breast cancer treatment: A prospective study', Journal of Personalized Medicine, vol. 5, no. 3, pp. 326-340. https://doi.org/10.3390/jpm5030326
Fu, Mei ; Axelrod, Deborah ; Guth, Amber A. ; Fletcher, Jason ; Qiu, Jeanna M. ; Scagliola, Joan ; Kleinman, Robin ; Ryan, Caitlin E. ; Chan, Nicholas ; Haber, Judith. / Patterns of obesity and lymph fluid level during the first year of breast cancer treatment : A prospective study. In: Journal of Personalized Medicine. 2015 ; Vol. 5, No. 3. pp. 326-340.
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