Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome

Toufic A. Kabbani, Ciaran P. Kelly, Rebecca Betensky, Joshua Hansen, Kumar Pallav, Javier A. Villafuerte-Gálvez, Rohini Vanga, Rupa Mukherjee, Aileen Novero, Melinda Dennis, Daniel A. Leffler

Research output: Contribution to journalArticle

Abstract

Background & Aims: We investigated whether risk for non-insulin-dependent diabetes mellitus (NIDDM) and metabolic syndrome are affected by celiac disease. We examined the prevalence of NIDDM and metabolic syndrome among adults with celiac disease, compared with matched controls. Methods: We assessed medical records of 840 patients with biopsy-proven celiac disease for diagnoses of NIDDM, hypertension, or hyperlipidemia; body mass index (BMI); lipid profile; and levels of glucose or glycosylated hemoglobin, to identify those with metabolic syndrome. Patients without celiac disease were matched for age, sex, and ethnicity (n = 840 controls). The prevalence of NIDDM and metabolic syndrome in the celiac disease cohort was compared with that of the controls and subjects included in the National Health and Nutrition Examination Survey. Results: Twenty-six patients with celiac disease (3.1%) had NIDDM compared with 81 controls (9.6%) (P <.0001). Similarly, the prevalence of metabolic syndrome was significantly lower among patients with celiac disease than controls (3.5% vs 12.7%; P <.0001). The mean BMI of patients with celiac disease was significantly lower than that of controls (24.7 vs 27.5; P <.0001). However, celiac disease was still associated with a lower risk of NIDDM, after controlling for BMI. Conclusions: The prevalence of NIDDM and metabolic syndrome are lower among patients with celiac disease than in matched controls and the general population. These differences are not explained by differences in BMI. Studies are needed to determine the mechanisms by which celiac disease affects the risk for NIDDM and metabolic syndrome.

Original languageEnglish (US)
JournalGastroenterology
Volume144
Issue number5
DOIs
StatePublished - Jan 1 2013

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Celiac Disease
Type 2 Diabetes Mellitus
Body Mass Index
Nutrition Surveys
Glycosylated Hemoglobin A
Hyperlipidemias
Medical Records
Hypertension
Lipids
Biopsy
Glucose

Keywords

  • Gluten Sensitivity
  • NHANES
  • Obesity
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome. / Kabbani, Toufic A.; Kelly, Ciaran P.; Betensky, Rebecca; Hansen, Joshua; Pallav, Kumar; Villafuerte-Gálvez, Javier A.; Vanga, Rohini; Mukherjee, Rupa; Novero, Aileen; Dennis, Melinda; Leffler, Daniel A.

In: Gastroenterology, Vol. 144, No. 5, 01.01.2013.

Research output: Contribution to journalArticle

Kabbani, TA, Kelly, CP, Betensky, R, Hansen, J, Pallav, K, Villafuerte-Gálvez, JA, Vanga, R, Mukherjee, R, Novero, A, Dennis, M & Leffler, DA 2013, 'Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome', Gastroenterology, vol. 144, no. 5. https://doi.org/10.1053/j.gastro.2013.01.033
Kabbani, Toufic A. ; Kelly, Ciaran P. ; Betensky, Rebecca ; Hansen, Joshua ; Pallav, Kumar ; Villafuerte-Gálvez, Javier A. ; Vanga, Rohini ; Mukherjee, Rupa ; Novero, Aileen ; Dennis, Melinda ; Leffler, Daniel A. / Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome. In: Gastroenterology. 2013 ; Vol. 144, No. 5.
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abstract = "Background & Aims: We investigated whether risk for non-insulin-dependent diabetes mellitus (NIDDM) and metabolic syndrome are affected by celiac disease. We examined the prevalence of NIDDM and metabolic syndrome among adults with celiac disease, compared with matched controls. Methods: We assessed medical records of 840 patients with biopsy-proven celiac disease for diagnoses of NIDDM, hypertension, or hyperlipidemia; body mass index (BMI); lipid profile; and levels of glucose or glycosylated hemoglobin, to identify those with metabolic syndrome. Patients without celiac disease were matched for age, sex, and ethnicity (n = 840 controls). The prevalence of NIDDM and metabolic syndrome in the celiac disease cohort was compared with that of the controls and subjects included in the National Health and Nutrition Examination Survey. Results: Twenty-six patients with celiac disease (3.1{\%}) had NIDDM compared with 81 controls (9.6{\%}) (P <.0001). Similarly, the prevalence of metabolic syndrome was significantly lower among patients with celiac disease than controls (3.5{\%} vs 12.7{\%}; P <.0001). The mean BMI of patients with celiac disease was significantly lower than that of controls (24.7 vs 27.5; P <.0001). However, celiac disease was still associated with a lower risk of NIDDM, after controlling for BMI. Conclusions: The prevalence of NIDDM and metabolic syndrome are lower among patients with celiac disease than in matched controls and the general population. These differences are not explained by differences in BMI. Studies are needed to determine the mechanisms by which celiac disease affects the risk for NIDDM and metabolic syndrome.",
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AU - Kabbani, Toufic A.

AU - Kelly, Ciaran P.

AU - Betensky, Rebecca

AU - Hansen, Joshua

AU - Pallav, Kumar

AU - Villafuerte-Gálvez, Javier A.

AU - Vanga, Rohini

AU - Mukherjee, Rupa

AU - Novero, Aileen

AU - Dennis, Melinda

AU - Leffler, Daniel A.

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Y1 - 2013/1/1

N2 - Background & Aims: We investigated whether risk for non-insulin-dependent diabetes mellitus (NIDDM) and metabolic syndrome are affected by celiac disease. We examined the prevalence of NIDDM and metabolic syndrome among adults with celiac disease, compared with matched controls. Methods: We assessed medical records of 840 patients with biopsy-proven celiac disease for diagnoses of NIDDM, hypertension, or hyperlipidemia; body mass index (BMI); lipid profile; and levels of glucose or glycosylated hemoglobin, to identify those with metabolic syndrome. Patients without celiac disease were matched for age, sex, and ethnicity (n = 840 controls). The prevalence of NIDDM and metabolic syndrome in the celiac disease cohort was compared with that of the controls and subjects included in the National Health and Nutrition Examination Survey. Results: Twenty-six patients with celiac disease (3.1%) had NIDDM compared with 81 controls (9.6%) (P <.0001). Similarly, the prevalence of metabolic syndrome was significantly lower among patients with celiac disease than controls (3.5% vs 12.7%; P <.0001). The mean BMI of patients with celiac disease was significantly lower than that of controls (24.7 vs 27.5; P <.0001). However, celiac disease was still associated with a lower risk of NIDDM, after controlling for BMI. Conclusions: The prevalence of NIDDM and metabolic syndrome are lower among patients with celiac disease than in matched controls and the general population. These differences are not explained by differences in BMI. Studies are needed to determine the mechanisms by which celiac disease affects the risk for NIDDM and metabolic syndrome.

AB - Background & Aims: We investigated whether risk for non-insulin-dependent diabetes mellitus (NIDDM) and metabolic syndrome are affected by celiac disease. We examined the prevalence of NIDDM and metabolic syndrome among adults with celiac disease, compared with matched controls. Methods: We assessed medical records of 840 patients with biopsy-proven celiac disease for diagnoses of NIDDM, hypertension, or hyperlipidemia; body mass index (BMI); lipid profile; and levels of glucose or glycosylated hemoglobin, to identify those with metabolic syndrome. Patients without celiac disease were matched for age, sex, and ethnicity (n = 840 controls). The prevalence of NIDDM and metabolic syndrome in the celiac disease cohort was compared with that of the controls and subjects included in the National Health and Nutrition Examination Survey. Results: Twenty-six patients with celiac disease (3.1%) had NIDDM compared with 81 controls (9.6%) (P <.0001). Similarly, the prevalence of metabolic syndrome was significantly lower among patients with celiac disease than controls (3.5% vs 12.7%; P <.0001). The mean BMI of patients with celiac disease was significantly lower than that of controls (24.7 vs 27.5; P <.0001). However, celiac disease was still associated with a lower risk of NIDDM, after controlling for BMI. Conclusions: The prevalence of NIDDM and metabolic syndrome are lower among patients with celiac disease than in matched controls and the general population. These differences are not explained by differences in BMI. Studies are needed to determine the mechanisms by which celiac disease affects the risk for NIDDM and metabolic syndrome.

KW - Gluten Sensitivity

KW - NHANES

KW - Obesity

KW - Type 2 Diabetes

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