Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury

Andrei Irimia, Micah C. Chambers, Carinna M. Torgerson, Maria Filippou, David A. Hovda, Jeffry R. ALger, Guido Gerig, Arthur W. Toga, Paul M. Vespa, Ron Kikinis, John D. Van Horn

    Research output: Contribution to journalArticle

    Abstract

    Available approaches to the investigation of traumatic brain injury (TBI) are frequently hampered, to some extent, by the unsatisfactory abilities of existing methodologies to efficiently define and represent affected structural connectivity and functional mechanisms underlying TBI-related pathology. In this paper, we describe a patient-tailored framework which allows mapping and characterization of TBI-related structural damage to the brain via multimodal neuroimaging and personalized connectomics. Specifically, we introduce a graphically driven approach for the assessment of trauma-related atrophy of white matter connections between cortical structures, with relevance to the quantification of TBI chronic case evolution.This approach allows one to inform the formulation of graphical neurophysi-ological and neuropsychologicalTBI profiles based on the particular structural deficits of the affected patient. In addition, it allows one to relate the findings supplied by our workflow to the existing body of research that focuses on the functional roles of the cortical structures being targeted. A graphical means for representing patient TBI status is relevant to the emerging field of personalized medicine and to the investigation of neural atrophy.

    Original languageEnglish (US)
    Article numberArticle 10
    JournalFrontiers in Neurology
    VolumeFEB
    DOIs
    StatePublished - 2012

    Fingerprint

    Connectome
    Atrophy
    Precision Medicine
    Workflow
    Neuroimaging
    White Matter
    Traumatic Brain Injury
    Pathology
    Wounds and Injuries
    Brain
    Research

    Keywords

    • Atrophy
    • Connectomics
    • DTI
    • Rehabilitation
    • Traumatic brain injury

    ASJC Scopus subject areas

    • Clinical Neurology
    • Neurology

    Cite this

    Irimia, A., Chambers, M. C., Torgerson, C. M., Filippou, M., Hovda, D. A., ALger, J. R., ... Van Horn, J. D. (2012). Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. Frontiers in Neurology, FEB, [Article 10]. https://doi.org/10.3389/fneur.2012.00010

    Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. / Irimia, Andrei; Chambers, Micah C.; Torgerson, Carinna M.; Filippou, Maria; Hovda, David A.; ALger, Jeffry R.; Gerig, Guido; Toga, Arthur W.; Vespa, Paul M.; Kikinis, Ron; Van Horn, John D.

    In: Frontiers in Neurology, Vol. FEB, Article 10, 2012.

    Research output: Contribution to journalArticle

    Irimia, A, Chambers, MC, Torgerson, CM, Filippou, M, Hovda, DA, ALger, JR, Gerig, G, Toga, AW, Vespa, PM, Kikinis, R & Van Horn, JD 2012, 'Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury', Frontiers in Neurology, vol. FEB, Article 10. https://doi.org/10.3389/fneur.2012.00010
    Irimia, Andrei ; Chambers, Micah C. ; Torgerson, Carinna M. ; Filippou, Maria ; Hovda, David A. ; ALger, Jeffry R. ; Gerig, Guido ; Toga, Arthur W. ; Vespa, Paul M. ; Kikinis, Ron ; Van Horn, John D. / Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. In: Frontiers in Neurology. 2012 ; Vol. FEB.
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