Abstract
Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription. Understanding the mechanism of how HDACs affect osteoblast differentiation and mineralization will identify new theraupeutic methods for bone diseases, such as osteoporosis and multiple myeloma.
| Original language | English (US) |
|---|---|
| Title of host publication | Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling |
| Pages | 349-353 |
| Number of pages | 5 |
| Volume | 1116 |
| DOIs | |
| State | Published - Nov 2007 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1116 |
| ISSN (Print) | 00778923 |
| ISSN (Electronic) | 17496632 |
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Keywords
- Histone deacetylases
- Osteoblasts
- Parathyroid hormone
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Parathyroid hormone regulates histone deacetylases in osteoblasts. / Shimizu, Emi; Selvamurugan, Nagarajan; Westendorf, Jennifer J.; Partridge, Nicola.
Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. Vol. 1116 2007. p. 349-353 (Annals of the New York Academy of Sciences; Vol. 1116).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Parathyroid hormone regulates histone deacetylases in osteoblasts
AU - Shimizu, Emi
AU - Selvamurugan, Nagarajan
AU - Westendorf, Jennifer J.
AU - Partridge, Nicola
PY - 2007/11
Y1 - 2007/11
N2 - Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription. Understanding the mechanism of how HDACs affect osteoblast differentiation and mineralization will identify new theraupeutic methods for bone diseases, such as osteoporosis and multiple myeloma.
AB - Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription. Understanding the mechanism of how HDACs affect osteoblast differentiation and mineralization will identify new theraupeutic methods for bone diseases, such as osteoporosis and multiple myeloma.
KW - Histone deacetylases
KW - Osteoblasts
KW - Parathyroid hormone
UR - http://www.scopus.com/inward/record.url?scp=37249016934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37249016934&partnerID=8YFLogxK
U2 - 10.1196/annals.1402.037
DO - 10.1196/annals.1402.037
M3 - Conference contribution
SN - 9781573316842
VL - 1116
T3 - Annals of the New York Academy of Sciences
SP - 349
EP - 353
BT - Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling
ER -