Abstract
Parathyroid hormone (PTH) is the major hormone regulating calcium metabolism. It is also the only FDA-approved drug for osteoporosis treatment that stimulates bone formation when injected daily. However, continuous infusion of PTH causes severe bone loss in line with its known catabolic effects. Many studies to understand the dual effects of PTH have been carried out, and in recent years a growing number of molecular and cellular mechanisms underlying these effects have emerged. Here, we outline the present knowledge and conclude that the kinetics of administration and subsequent signaling probably account for the divergent actions of the hormone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 60-65 |
| Number of pages | 6 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2004 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Parathyroid hormone : A double-edged sword for bone metabolism. / Qin, Ling; Raggatt, Liza J.; Partridge, Nicola.
In: Trends in Endocrinology and Metabolism, Vol. 15, No. 2, 03.2004, p. 60-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parathyroid hormone
T2 - A double-edged sword for bone metabolism
AU - Qin, Ling
AU - Raggatt, Liza J.
AU - Partridge, Nicola
PY - 2004/3
Y1 - 2004/3
N2 - Parathyroid hormone (PTH) is the major hormone regulating calcium metabolism. It is also the only FDA-approved drug for osteoporosis treatment that stimulates bone formation when injected daily. However, continuous infusion of PTH causes severe bone loss in line with its known catabolic effects. Many studies to understand the dual effects of PTH have been carried out, and in recent years a growing number of molecular and cellular mechanisms underlying these effects have emerged. Here, we outline the present knowledge and conclude that the kinetics of administration and subsequent signaling probably account for the divergent actions of the hormone.
AB - Parathyroid hormone (PTH) is the major hormone regulating calcium metabolism. It is also the only FDA-approved drug for osteoporosis treatment that stimulates bone formation when injected daily. However, continuous infusion of PTH causes severe bone loss in line with its known catabolic effects. Many studies to understand the dual effects of PTH have been carried out, and in recent years a growing number of molecular and cellular mechanisms underlying these effects have emerged. Here, we outline the present knowledge and conclude that the kinetics of administration and subsequent signaling probably account for the divergent actions of the hormone.
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U2 - 10.1016/j.tem.2004.01.006
DO - 10.1016/j.tem.2004.01.006
M3 - Article
VL - 15
SP - 60
EP - 65
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 2
ER -