Parallel molecular pathways mediate expression of distinct forms of intermediate-term facilitation at tail sensory-motor synapses in Aplysia

Michael A. Sutton, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Three distinct temporal phases of synaptic facilitation (short-, intermediate-, and long-term) are induced by serotonin (5-HT) at sensory (SN) to motor (MN) synapses in Aplysia. Here, we characterize two mechanistically distinct forms of intermediate-term faciliation (ITF) at tail SN-MN synapses. One form, activity-independent ITF, is produced by five spaced pulses of 5-HT in the absence of SN activity. Its induction requires protein synthesis, and its expression requires persistent activation of PKA but not PKC. The other form, activity-dependent ITF, is produced by a single pulse of 5-HT coincident with SN activation. Its induction does not require protein synthesis, and its expression requires persistent activation of PKC but not PKA. These results demonstrate that SN-MN synapses can exhibit two distinct forms of ITF that are mediated by parallel molecular pathways.

Original languageEnglish (US)
Pages (from-to)219-231
Number of pages13
JournalNeuron
Volume26
Issue number1
StatePublished - 2000

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Aplysia
Synapses
Tail
Serotonin
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

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Parallel molecular pathways mediate expression of distinct forms of intermediate-term facilitation at tail sensory-motor synapses in Aplysia. / Sutton, Michael A.; Carew, Thomas.

In: Neuron, Vol. 26, No. 1, 2000, p. 219-231.

Research output: Contribution to journalArticle

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