Paradoxical response reversal of top- down modulation in cortical circuits with three interneuron types

Luis Carlos Garcia Del Molino, Guangyu Robert Yang, Jorge F. Mejias, Xiao-Jing Wang

Research output: Contribution to journalArticle

Abstract

Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex. Experiments recording from this circuit often report counterintuitive and seemingly contradictory findings. For example, the response of SST cells in mouse V1 to top-down behavioral modulation can change its sign when the visual input changes, a phenomenon that we call response reversal. We developed a theoretical framework to explain these seemingly contradictory effects as emerging phenomena in circuits with two key features: interactions between multiple neural populations and a nonlinear neuronal input-output relationship. Furthermore, we built a cortical circuit model which reproduces counterintuitive dynamics observed in mouse V1. Our analytical calculations pinpoint connection properties critical to response reversal, and predict additional novel types of complex dynamics that could be tested in future experiments.

Original languageEnglish (US)
Article numbere29742
JournaleLife
Volume6
DOIs
StatePublished - Dec 19 2017

Fingerprint

Interneurons
Modulation
Somatostatin
Parvalbumins
Somatostatin-Secreting Cells
Networks (circuits)
Pyramidal Cells
Vasoactive Intestinal Peptide
Experiments
Population

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Paradoxical response reversal of top- down modulation in cortical circuits with three interneuron types. / Garcia Del Molino, Luis Carlos; Yang, Guangyu Robert; Mejias, Jorge F.; Wang, Xiao-Jing.

In: eLife, Vol. 6, e29742, 19.12.2017.

Research output: Contribution to journalArticle

Garcia Del Molino, Luis Carlos ; Yang, Guangyu Robert ; Mejias, Jorge F. ; Wang, Xiao-Jing. / Paradoxical response reversal of top- down modulation in cortical circuits with three interneuron types. In: eLife. 2017 ; Vol. 6.
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