Abstract
Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex. Experiments recording from this circuit often report counterintuitive and seemingly contradictory findings. For example, the response of SST cells in mouse V1 to top-down behavioral modulation can change its sign when the visual input changes, a phenomenon that we call response reversal. We developed a theoretical framework to explain these seemingly contradictory effects as emerging phenomena in circuits with two key features: interactions between multiple neural populations and a nonlinear neuronal input-output relationship. Furthermore, we built a cortical circuit model which reproduces counterintuitive dynamics observed in mouse V1. Our analytical calculations pinpoint connection properties critical to response reversal, and predict additional novel types of complex dynamics that could be tested in future experiments.
| Original language | English (US) |
|---|---|
| Article number | e29742 |
| Journal | eLife |
| Volume | 6 |
| DOIs | |
| State | Published - Dec 19 2017 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
Cite this
Paradoxical response reversal of top- down modulation in cortical circuits with three interneuron types. / Garcia Del Molino, Luis Carlos; Yang, Guangyu Robert; Mejias, Jorge F.; Wang, Xiao-Jing.
In: eLife, Vol. 6, e29742, 19.12.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paradoxical response reversal of top- down modulation in cortical circuits with three interneuron types
AU - Garcia Del Molino, Luis Carlos
AU - Yang, Guangyu Robert
AU - Mejias, Jorge F.
AU - Wang, Xiao-Jing
PY - 2017/12/19
Y1 - 2017/12/19
N2 - Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex. Experiments recording from this circuit often report counterintuitive and seemingly contradictory findings. For example, the response of SST cells in mouse V1 to top-down behavioral modulation can change its sign when the visual input changes, a phenomenon that we call response reversal. We developed a theoretical framework to explain these seemingly contradictory effects as emerging phenomena in circuits with two key features: interactions between multiple neural populations and a nonlinear neuronal input-output relationship. Furthermore, we built a cortical circuit model which reproduces counterintuitive dynamics observed in mouse V1. Our analytical calculations pinpoint connection properties critical to response reversal, and predict additional novel types of complex dynamics that could be tested in future experiments.
AB - Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex. Experiments recording from this circuit often report counterintuitive and seemingly contradictory findings. For example, the response of SST cells in mouse V1 to top-down behavioral modulation can change its sign when the visual input changes, a phenomenon that we call response reversal. We developed a theoretical framework to explain these seemingly contradictory effects as emerging phenomena in circuits with two key features: interactions between multiple neural populations and a nonlinear neuronal input-output relationship. Furthermore, we built a cortical circuit model which reproduces counterintuitive dynamics observed in mouse V1. Our analytical calculations pinpoint connection properties critical to response reversal, and predict additional novel types of complex dynamics that could be tested in future experiments.
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U2 - 10.7554/eLife.29742
DO - 10.7554/eLife.29742
M3 - Article
C2 - 29256863
AN - SCOPUS:85041282171
VL - 6
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e29742
ER -