Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Yelena Margolin, Jean Francois Cloutier, Vladimir Shafirovich, Nicholas Geacintov, Peter C. Dedon

Research output: Contribution to journalArticle

Abstract

Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

Original languageEnglish (US)
Pages (from-to)365-366
Number of pages2
JournalNature Chemical Biology
Volume2
Issue number7
DOIs
StatePublished - Jul 2006

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Inflammation Mediators
Guanine
DNA
Oxidants

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. / Margolin, Yelena; Cloutier, Jean Francois; Shafirovich, Vladimir; Geacintov, Nicholas; Dedon, Peter C.

In: Nature Chemical Biology, Vol. 2, No. 7, 07.2006, p. 365-366.

Research output: Contribution to journalArticle

Margolin, Yelena ; Cloutier, Jean Francois ; Shafirovich, Vladimir ; Geacintov, Nicholas ; Dedon, Peter C. / Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. In: Nature Chemical Biology. 2006 ; Vol. 2, No. 7. pp. 365-366.
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