Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami, Sreekumar Pankajakshan, Gang Chen, Teck Peng Loh

Research output: Contribution to journalArticle

Abstract

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Original languageEnglish (US)
Pages (from-to)4223-4226
Number of pages4
JournalOrganic Letters
Volume19
Issue number16
DOIs
StatePublished - Aug 18 2017

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Palladium
Amides
amides
palladium
Reaction intermediates
reaction intermediates
peptides
amino acids
Amino Acids
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Maraswami, M., Pankajakshan, S., Chen, G., & Loh, T. P. (2017). Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides. Organic Letters, 19(16), 4223-4226. https://doi.org/10.1021/acs.orglett.7b01859

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides. / Maraswami, Manikantha; Pankajakshan, Sreekumar; Chen, Gang; Loh, Teck Peng.

In: Organic Letters, Vol. 19, No. 16, 18.08.2017, p. 4223-4226.

Research output: Contribution to journalArticle

Maraswami, M, Pankajakshan, S, Chen, G & Loh, TP 2017, 'Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides', Organic Letters, vol. 19, no. 16, pp. 4223-4226. https://doi.org/10.1021/acs.orglett.7b01859
Maraswami, Manikantha ; Pankajakshan, Sreekumar ; Chen, Gang ; Loh, Teck Peng. / Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides. In: Organic Letters. 2017 ; Vol. 19, No. 16. pp. 4223-4226.
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