Palladium-catalyzed couplings to nucleophilic heteroarenes: The total synthesis of (-)-frondosin B

Chambers C. Hughes, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

The total synthesis of (-)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. Graphical Abstract.

Original languageEnglish (US)
Pages (from-to)9675-9686
Number of pages12
JournalTetrahedron
Volume60
Issue number43 SPEC. ISS.
DOIs
StatePublished - Oct 18 2004

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Keywords

  • Frondosin
  • Heck reaction
  • Palladium catalysis
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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