Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments

Conor Crean, Nicholas Geacintov, Vladimir Shafirovich

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).

Original languageEnglish (US)
Pages (from-to)5057-5060
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number32
DOIs
StatePublished - Aug 12 2005

Fingerprint

Oxidative stress
Carbonates
Guanine
Labeling
Anions
Oxygen
Oxidation
Experiments
8-hydroxyguanine

Keywords

  • DNA damage
  • Isotopic labeling
  • Oxidation
  • Radical reactions
  • Reaction mechanisms

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions : Insight from oxygen-18 labeling experiments. / Crean, Conor; Geacintov, Nicholas; Shafirovich, Vladimir.

In: Angewandte Chemie - International Edition, Vol. 44, No. 32, 12.08.2005, p. 5057-5060.

Research output: Contribution to journalArticle

@article{4563e4fe618c48ca89b97a3844f27361,
title = "Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments",
abstract = "(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).",
keywords = "DNA damage, Isotopic labeling, Oxidation, Radical reactions, Reaction mechanisms",
author = "Conor Crean and Nicholas Geacintov and Vladimir Shafirovich",
year = "2005",
month = "8",
day = "12",
doi = "10.1002/anie.200500991",
language = "English (US)",
volume = "44",
pages = "5057--5060",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "32",

}

TY - JOUR

T1 - Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions

T2 - Insight from oxygen-18 labeling experiments

AU - Crean, Conor

AU - Geacintov, Nicholas

AU - Shafirovich, Vladimir

PY - 2005/8/12

Y1 - 2005/8/12

N2 - (Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).

AB - (Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).

KW - DNA damage

KW - Isotopic labeling

KW - Oxidation

KW - Radical reactions

KW - Reaction mechanisms

UR - http://www.scopus.com/inward/record.url?scp=23944508507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944508507&partnerID=8YFLogxK

U2 - 10.1002/anie.200500991

DO - 10.1002/anie.200500991

M3 - Article

C2 - 16013075

AN - SCOPUS:23944508507

VL - 44

SP - 5057

EP - 5060

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 32

ER -