Overcoming suppression in order to remember: Contributions from anterior cingulate and ventrolateral prefrontal cortex

Brice A. Kuhl, Itamar Kahn, Nicole M. Dudukovic, Anthony D. Wagner

Research output: Contribution to journalArticle

Abstract

The ability to remember is often compromised by competition from irrelevant memories. However, acts of selective remembering can alter the competitive relationship between memories; memories that are selected against are weakened, whereas those that are retrieved are strengthened. Whereas the weakening of selected-against memories is typically evidenced by subsequently poorer recall of these memories, the present study tested the hypothesis that when previously selected-against memories can subsequently be successfully retrieved, such acts of successful retrieval are associated with engagement of neurobiological mechanisms that serve to detect and overcome competition. Consistent with this hypothesis, fMRI revealed that anterior cingulate cortex and right ventrolateral prefrontal cortex are differentially engaged during successful retrieval of previously selected-against memories, and that their engagement is directly related to the magnitude of weakening that is induced by prior acts of selecting against these memories.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalCognitive, Affective and Behavioral Neuroscience
Volume8
Issue number2
DOIs
StatePublished - Jun 2008

Fingerprint

Gyrus Cinguli
Prefrontal Cortex
Aptitude
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience

Cite this

Overcoming suppression in order to remember : Contributions from anterior cingulate and ventrolateral prefrontal cortex. / Kuhl, Brice A.; Kahn, Itamar; Dudukovic, Nicole M.; Wagner, Anthony D.

In: Cognitive, Affective and Behavioral Neuroscience, Vol. 8, No. 2, 06.2008, p. 211-221.

Research output: Contribution to journalArticle

Kuhl, Brice A. ; Kahn, Itamar ; Dudukovic, Nicole M. ; Wagner, Anthony D. / Overcoming suppression in order to remember : Contributions from anterior cingulate and ventrolateral prefrontal cortex. In: Cognitive, Affective and Behavioral Neuroscience. 2008 ; Vol. 8, No. 2. pp. 211-221.
@article{523e6972531c4b32aa085bb11fa2254a,
title = "Overcoming suppression in order to remember: Contributions from anterior cingulate and ventrolateral prefrontal cortex",
abstract = "The ability to remember is often compromised by competition from irrelevant memories. However, acts of selective remembering can alter the competitive relationship between memories; memories that are selected against are weakened, whereas those that are retrieved are strengthened. Whereas the weakening of selected-against memories is typically evidenced by subsequently poorer recall of these memories, the present study tested the hypothesis that when previously selected-against memories can subsequently be successfully retrieved, such acts of successful retrieval are associated with engagement of neurobiological mechanisms that serve to detect and overcome competition. Consistent with this hypothesis, fMRI revealed that anterior cingulate cortex and right ventrolateral prefrontal cortex are differentially engaged during successful retrieval of previously selected-against memories, and that their engagement is directly related to the magnitude of weakening that is induced by prior acts of selecting against these memories.",
author = "Kuhl, {Brice A.} and Itamar Kahn and Dudukovic, {Nicole M.} and Wagner, {Anthony D.}",
year = "2008",
month = "6",
doi = "10.3758/CABN.8.2.211",
language = "English (US)",
volume = "8",
pages = "211--221",
journal = "Cognitive, Affective and Behavioral Neuroscience",
issn = "1530-7026",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Overcoming suppression in order to remember

T2 - Contributions from anterior cingulate and ventrolateral prefrontal cortex

AU - Kuhl, Brice A.

AU - Kahn, Itamar

AU - Dudukovic, Nicole M.

AU - Wagner, Anthony D.

PY - 2008/6

Y1 - 2008/6

N2 - The ability to remember is often compromised by competition from irrelevant memories. However, acts of selective remembering can alter the competitive relationship between memories; memories that are selected against are weakened, whereas those that are retrieved are strengthened. Whereas the weakening of selected-against memories is typically evidenced by subsequently poorer recall of these memories, the present study tested the hypothesis that when previously selected-against memories can subsequently be successfully retrieved, such acts of successful retrieval are associated with engagement of neurobiological mechanisms that serve to detect and overcome competition. Consistent with this hypothesis, fMRI revealed that anterior cingulate cortex and right ventrolateral prefrontal cortex are differentially engaged during successful retrieval of previously selected-against memories, and that their engagement is directly related to the magnitude of weakening that is induced by prior acts of selecting against these memories.

AB - The ability to remember is often compromised by competition from irrelevant memories. However, acts of selective remembering can alter the competitive relationship between memories; memories that are selected against are weakened, whereas those that are retrieved are strengthened. Whereas the weakening of selected-against memories is typically evidenced by subsequently poorer recall of these memories, the present study tested the hypothesis that when previously selected-against memories can subsequently be successfully retrieved, such acts of successful retrieval are associated with engagement of neurobiological mechanisms that serve to detect and overcome competition. Consistent with this hypothesis, fMRI revealed that anterior cingulate cortex and right ventrolateral prefrontal cortex are differentially engaged during successful retrieval of previously selected-against memories, and that their engagement is directly related to the magnitude of weakening that is induced by prior acts of selecting against these memories.

UR - http://www.scopus.com/inward/record.url?scp=52249103122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52249103122&partnerID=8YFLogxK

U2 - 10.3758/CABN.8.2.211

DO - 10.3758/CABN.8.2.211

M3 - Article

VL - 8

SP - 211

EP - 221

JO - Cognitive, Affective and Behavioral Neuroscience

JF - Cognitive, Affective and Behavioral Neuroscience

SN - 1530-7026

IS - 2

ER -