Outcomes in a series of 103 retroperitoneal sarcomas

J. P E N Pierie, Rebecca Betensky, U. Choudry, C. G. Willett, W. W. Souba, M. J. Ott

Research output: Contribution to journalArticle

Abstract

Aims: To report the effect on outcome of selection in patients receiving intra-operative electron beam radiation (IOERT) and external beam radiation therapy (EBRT). Methods: One hundred and three patients treated for primary RS were studied. Median follow-up was 27 months. Clinical presentation, tumor characteristics, and treatment methods were analyzed to determine impact on survival and recurrence and if selection was occurring. Results: Mean age was 55 ± 17 years. Mean tumor size was 15 ± 6 cm and 88 were high-grade. Complete gross tumor resection (CR) occurred in 62 patients and improved survival vs. both debulking (p = 0.0005) and biopsy (p < 0.0001). The 5- and 10-year survival rates were 62% and 52% for those with CR vs. 29% and 20% after incomplete resection. Among the 62 CR patients, there was selection to receive additional EBRT ± IOERT in patients with high-grade tumors (p = 0.005) and/or microscopically positive margins (p = 0.011). In these high-risk patients there was a trend for IOERT to further augment survival vs. EBRT alone and to increase the time to both local and distant recurrences (p = 0.036). Conclusions: Complete gross resection is the primary form of curative treatment for retroperitoneal sarcomas. Selection led to patients with high-risk tumors receiving additional radiation therapy. There appears to be a beneficial effect of IOERT plus EBRT in these high-risk patients after complete tumor resection.

Original languageEnglish (US)
Pages (from-to)1235-1241
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume32
Issue number10
DOIs
StatePublished - Dec 1 2006

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Sarcoma
Radiotherapy
Electrons
Radiation
Neoplasms
Patient Selection
Survival
Recurrence
Survival Rate
Biopsy
Therapeutics

Keywords

  • Intra-operative radiation therapy
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Pierie, J. P. E. N., Betensky, R., Choudry, U., Willett, C. G., Souba, W. W., & Ott, M. J. (2006). Outcomes in a series of 103 retroperitoneal sarcomas. European Journal of Surgical Oncology, 32(10), 1235-1241. https://doi.org/10.1016/j.ejso.2006.07.002

Outcomes in a series of 103 retroperitoneal sarcomas. / Pierie, J. P E N; Betensky, Rebecca; Choudry, U.; Willett, C. G.; Souba, W. W.; Ott, M. J.

In: European Journal of Surgical Oncology, Vol. 32, No. 10, 01.12.2006, p. 1235-1241.

Research output: Contribution to journalArticle

Pierie, JPEN, Betensky, R, Choudry, U, Willett, CG, Souba, WW & Ott, MJ 2006, 'Outcomes in a series of 103 retroperitoneal sarcomas', European Journal of Surgical Oncology, vol. 32, no. 10, pp. 1235-1241. https://doi.org/10.1016/j.ejso.2006.07.002
Pierie, J. P E N ; Betensky, Rebecca ; Choudry, U. ; Willett, C. G. ; Souba, W. W. ; Ott, M. J. / Outcomes in a series of 103 retroperitoneal sarcomas. In: European Journal of Surgical Oncology. 2006 ; Vol. 32, No. 10. pp. 1235-1241.
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