Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease

Patrick S. Randolph-Quinney, Scott Williams, Maryna Steyn, Marc R. Meyer, Jacqueline S. Smilg, Steven E. Churchill, Edward J. Odes, Tanya Augustine, Paul Tafforeau, Lee R. Berger

    Research output: Contribution to journalArticle

    Abstract

    We describe the earliest evidence for neoplastic disease in the hominin lineage. This is reported from the type specimen of the extinct hominin Australopithecus sediba from Malapa, South Africa, dated to 1.98 million years ago. The affected individual was male and developmentally equivalent to a human child of 12 to 13 years of age. A penetrating lytic lesion affected the sixth thoracic vertebra. The lesion was macroscopically evaluated and internally imaged through phase-contrast X-ray synchrotron microtomography. A comprehensive differential diagnosis was undertaken based on gross- and micro-morphology of the lesion, leading to a probable diagnosis of osteoid osteoma. These neoplasms are solitary, benign, osteoid and bone-forming tumours, formed from well-vascularised connective tissue within which there is active production of osteoid and woven bone. Tumours of any kind are rare in archaeological populations, and are all but unknown in the hominin record, highlighting the importance of this discovery. The presence of this disease at Malapa predates the earliest evidence of malignant neoplasia in the hominin fossil record by perhaps 200 000 years.

    Original languageEnglish (US)
    Article number20150470
    JournalSouth African Journal of Science
    Volume112
    Issue number7-8
    DOIs
    StatePublished - Jul 1 2016

    Fingerprint

    Hominidae
    lesion
    tumor
    Tumors
    Bone
    lesions (animal)
    neoplasms
    bone
    Prednisolone
    Synchrotrons
    Neoplasms
    micromorphology
    type specimen
    bones
    Tissue
    Osteoid Osteoma
    Thoracic Vertebrae
    fossil record
    micro-computed tomography
    X rays

    Keywords

    • Malapa
    • Malignant
    • Neoplasia
    • Osteoma
    • Palaeopathology
    • Taphonomy

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)
    • Earth and Planetary Sciences(all)

    Cite this

    Randolph-Quinney, P. S., Williams, S., Steyn, M., Meyer, M. R., Smilg, J. S., Churchill, S. E., ... Berger, L. R. (2016). Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease. South African Journal of Science, 112(7-8), [20150470]. https://doi.org/10.17159/sajs.2016/20150470

    Osteogenic tumour in Australopithecus sediba : Earliest hominin evidence for neoplastic disease. / Randolph-Quinney, Patrick S.; Williams, Scott; Steyn, Maryna; Meyer, Marc R.; Smilg, Jacqueline S.; Churchill, Steven E.; Odes, Edward J.; Augustine, Tanya; Tafforeau, Paul; Berger, Lee R.

    In: South African Journal of Science, Vol. 112, No. 7-8, 20150470, 01.07.2016.

    Research output: Contribution to journalArticle

    Randolph-Quinney, PS, Williams, S, Steyn, M, Meyer, MR, Smilg, JS, Churchill, SE, Odes, EJ, Augustine, T, Tafforeau, P & Berger, LR 2016, 'Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease', South African Journal of Science, vol. 112, no. 7-8, 20150470. https://doi.org/10.17159/sajs.2016/20150470
    Randolph-Quinney PS, Williams S, Steyn M, Meyer MR, Smilg JS, Churchill SE et al. Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease. South African Journal of Science. 2016 Jul 1;112(7-8). 20150470. https://doi.org/10.17159/sajs.2016/20150470
    Randolph-Quinney, Patrick S. ; Williams, Scott ; Steyn, Maryna ; Meyer, Marc R. ; Smilg, Jacqueline S. ; Churchill, Steven E. ; Odes, Edward J. ; Augustine, Tanya ; Tafforeau, Paul ; Berger, Lee R. / Osteogenic tumour in Australopithecus sediba : Earliest hominin evidence for neoplastic disease. In: South African Journal of Science. 2016 ; Vol. 112, No. 7-8.
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