Osteogenic effect of high-frequency acceleration on alveolar bone

M. Alikhani, E. Khoo, B. Alyami, M. Raptis, J. M. Salgueiro, S. M. Oliveira, A. Boskey, Cristina Teixeira

Research output: Contribution to journalArticle

Abstract

Mechanical stimulation contributes to the health of alveolar bone, but no therapy using the osteogenic effects of these stimuli to increase alveolar bone formation has been developed. We propose that the application of high-frequency acceleration to teeth in the absence of significant loading is osteogenic. Sprague-Dawley rats were divided among control, sham, and experimental groups. The experimental group underwent localized accelerations at different frequencies for 5 min/day on the occlusal surface of the maxillary right first molar at a very low magnitude of loading (4 με). Sham rats received a similar load in the absence of acceleration or frequency. The alveolar bone of the maxilla was evaluated by microcomputed tomography (μCT), histology, fluorescence microscopy, scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR imaging), and RT-PCR for osteogenic genes. Results demonstrate that application of high-frequency acceleration significantly increased alveolar bone formation. These effects were not restricted to the area of application, and loading could be replaced by frequency and acceleration. These studies propose a simple mechanical therapy that may play a significant role in alveolar bone formation and maintenance.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalJournal of Dental Research
Volume91
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Bone and Bones
Osteogenesis
Fourier Transform Infrared Spectroscopy
Play Therapy
X-Ray Microtomography
Maxilla
Fluorescence Microscopy
Electron Scanning Microscopy
Sprague Dawley Rats
Histology
Tooth
Maintenance
Polymerase Chain Reaction
Health
Genes
Therapeutics

Keywords

  • acceleration
  • bone formation
  • gene expression
  • high frequency
  • mineralization
  • strain

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Alikhani, M., Khoo, E., Alyami, B., Raptis, M., Salgueiro, J. M., Oliveira, S. M., ... Teixeira, C. (2012). Osteogenic effect of high-frequency acceleration on alveolar bone. Journal of Dental Research, 91(4), 413-419. https://doi.org/10.1177/0022034512438590

Osteogenic effect of high-frequency acceleration on alveolar bone. / Alikhani, M.; Khoo, E.; Alyami, B.; Raptis, M.; Salgueiro, J. M.; Oliveira, S. M.; Boskey, A.; Teixeira, Cristina.

In: Journal of Dental Research, Vol. 91, No. 4, 04.2012, p. 413-419.

Research output: Contribution to journalArticle

Alikhani, M, Khoo, E, Alyami, B, Raptis, M, Salgueiro, JM, Oliveira, SM, Boskey, A & Teixeira, C 2012, 'Osteogenic effect of high-frequency acceleration on alveolar bone', Journal of Dental Research, vol. 91, no. 4, pp. 413-419. https://doi.org/10.1177/0022034512438590
Alikhani M, Khoo E, Alyami B, Raptis M, Salgueiro JM, Oliveira SM et al. Osteogenic effect of high-frequency acceleration on alveolar bone. Journal of Dental Research. 2012 Apr;91(4):413-419. https://doi.org/10.1177/0022034512438590
Alikhani, M. ; Khoo, E. ; Alyami, B. ; Raptis, M. ; Salgueiro, J. M. ; Oliveira, S. M. ; Boskey, A. ; Teixeira, Cristina. / Osteogenic effect of high-frequency acceleration on alveolar bone. In: Journal of Dental Research. 2012 ; Vol. 91, No. 4. pp. 413-419.
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